On May 13, 2018, the Chargers signed White to a four-year, $3.11 million contract that includes a signing bonus of $654,441.[10]
"It's hard for me to talk about Kyzir because I get real excited. I don't want to jump the gun on him. I want to get him in some games and watch him play, but just watching him run around here and some of the things he did in the offseason, I get real excited talking about him. His speed. His attitude. His explosiveness. He just has great instincts as a football player. We had a hammer on him (in the draft)."[11]
During rookie minicamp in the 2018 season, Chargers' coaching staff announced their decision to move White to linebacker.[12] White adjusted to the new position quickly and immediately impressed coaching staff. During training camp, he began competing as the Chargers' starting weak side linebacker against Jatavis Brown.[13] Head coach Anthony Lynn named White the backup weakside linebacker behind Brown to start the regular season.[14] But an hour before kickoff in the Chargers' season-opener, it was reported Lynn has instead elected to start White alongside Kyle Emanuel and middle linebacker Denzel Perryman.[15]
White made his professional regular season debut and first career start on September 9, 2018, in the Chargers' season-opener against the Kansas City Chiefs and recorded six combined tackles in their 38–28 loss. On September 16, 2018, White recorded four solo tackles, broke up two passes, and made his first career interception during a 31–20 win at the Buffalo Bills in Week 2. He made his first career interception off a pass thrown by Bills' rookie quarterback Josh Allen intended for tight end Jason Croom, and returned it for a nine-yard gain in the game's fourth quarter.[16][17] In a Week 3 game at the Los Angeles Rams, White suffered a knee injury that required minor surgery, and he was inactive for the following four games (Weeks 4–8).[18] On November 3, 2018, the Chargers announced he was being placed on injured reserve.[19]
White was placed on the reserve/COVID-19 list by the Chargers on November 21, 2020 during the 2020 season,[21] and was reactivated on December 9.[22] On December 23, 2020, White was placed on injured reserve due to a hamstring injury.[23]
2021
White entered the 2021 season as the Chargers' starting linebacker and finished the season as the team's leading tackler with 144 tackles, one sack, two forced fumbles, three passes defensed, and two interceptions.
Philadelphia Eagles
On March 26, 2022, White signed a one-year contract, worth up to $5 million, with the Philadelphia Eagles.[24][25] In the 2022 season with the Eagles, White and the Eagles reached Super Bowl LVII, where they lost 38–35 to the Chiefs. White had four tackles in Super Bowl LVII.[26]