The name of Klisura has traditionally been associated with the heroism of its inhabitants during the April Uprising. The then-village was a centre of the revolution and Borimechkata ("the man who struggles a bear") who lived in the village was one of its leaders. Places of main interest are the Church of St Nicholas, the local Historical Museum, and historic homes such as Chervenakov's house, Pavurdzhiev's house, Kozinarov's house, etc. Klisura is the birthplace of Hristo G. Danov, the founder of the first Bulgarian printing house in Plovdiv.
One and a half kilometres away from Klisura is Zli dol ("Evil glen"), the motor tourism complex of the Union of the Bulgarian Drivers. The complex includes 15 small houses with around 60 beds, a restaurant, a bar, a playground, tennis, volleyball and basketball courts, an equestrian area, and a guarded car park.
Klisura is a starting point for many itineraries to the Central Balkan National Park and to two peaks — Vezhen in the Balkan Mountains and Bogdan in Sredna Gora. The town is only one kilometre away from the Sub-Balkan principal highway thoroughfare Sofia-Burgas and has two railway stations.