In 1904, the Congregation of the Missionary Sisters of Our Lady of Africa established a health centre at Kisubi to help those suffering from sleeping sickness, which was prevalent in the area at that time. Over the next 110 years, the facility has expanded into a fully fledged hospital, with 110 beds.[3] On four occasions, before March 2010, the hospital conducted free surgeries to patients who could not afford the cost.[5]
In 2019, the hospital opened a new heart treatment centre, capable of performing a cardiac catheterization procedure. This cath-lab is one of the only two such labs in Uganda, as of January 2020. The other cardiac catheterization laboratory in the county is located at the Uganda Heart Institute in Mulago Hospital Complex, in Kampala.[6]