The major economic activity in Karene is farming. The Temne people is the predominant majority ethnic group in Karene.
Administrative divisions
Chiefdoms
After the 2017 local administrative reorganization, Kerene District has made up of thirteen chiefdoms as the third level of administrative subdivision.
Prior to the 2017 local administrative reorganization, Libeisaygahun, Sanda Loko, Sanda Tenraren, Sella Limba and Tambakha Chiefdoms were formerly from Bombali District; and were Buya Romende, Debia and Sanda Magbolontor Chiefdoms were formerly from Port Loko District.