KHDRBS1

KHDRBS1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKHDRBS1, Sam68, p62, p68, KH domain containing, RNA binding, signal transduction associated 1, KH RNA binding domain containing, signal transduction associated 1
External IDsOMIM: 602489; MGI: 893579; HomoloGene: 4781; GeneCards: KHDRBS1; OMA:KHDRBS1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

10657

20218

Ensembl

ENSG00000121774

ENSMUSG00000028790

UniProt

Q07666

Q60749

RefSeq (mRNA)

NM_001271878
NM_006559

NM_011317

RefSeq (protein)

NP_001258807
NP_006550

NP_035447

Location (UCSC)Chr 1: 32.01 – 32.06 MbChr 4: 129.6 – 129.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

KH domain-containing, RNA-binding, signal transduction-associated protein 1 is a protein that in humans is encoded by the KHDRBS1 gene.[5][6]

This gene encodes a member of the K homology domain-containing, RNA-binding, signal transduction-associated protein family. The encoded protein appears to have many functions and may be involved in a variety of cellular processes, including alternative splicing, cell cycle regulation, RNA 3'-end formation, tumorigenesis, and regulation of human immunodeficiency virus gene expression.[7]

Function

Sam68 (the Src-Associated substrate in Mitosis of 68 kDa) is officially called KHDRBS1 (KH domain containing, RNA binding, signal transduction associated 1). Sam68 is a KH-type RNA binding protein that recognizes U(U/A)AA direct repeats with relative high affinity.[8][9] Sam68 is predominantly nuclear and its major function in the nucleus is to regulate alternative splicing by recognizing RNA sequences neighboring the included/excluded exon(s).

Clinical significance

Sam68 influences the alternative splicing of a number of genes central to processes such as neurogenesis and adipogenesis as well as diseases such as spinal muscular atrophy (SMA) and cancer.

Neurogenesis

Sam68 was demonstrated to be involved in the alternative splicing of mRNAs implicated in normal neurogenesis using splicing-sensitive microarrays.[10] Sam68 was also shown to participate in the epithelial-to-mesenchymal transition by regulating the alternative splicing of SF2/ASF.[11] Sam68 was shown to regulate the activity-dependent alternative splicing of the neurexin-1 in the central nervous system with implications for neurodevelopment disorders.[12]

Adipogenesis

Sam68 influences alternative splicing of the mTOR kinase contributing to the lean phenotype observed in the Sam68 deficient mice.[13]

Spinal muscular atrophy

The role of Sam68 was further highlighted in spinal muscular atrophy (SMA), as Sam68 promotes the skipping of exon 7 leading to a non-functional SMN2 protein.[11]

Cancer

Sam68 regulates the alternative splicing of a number of cancer-related genes.

Direct evidence for the involvement of Sam68 in alternative splicing has been shown in promoting the inclusion of the variable exon 5 (v5) in CD44 correlating with cell migration potential.[14][15] CD44 is a cell surface protein whose expression has been linked to cancer, with its expression predicting prognosis in a number of tumour types.[16][17] In prostate cancer, Sam68 also interacts with splicing complex proteins KHDRBS3 (T-STAR) and Metadherin (MTDH) which also alter CD44 splicing.[17] Subsequently, the knockdown of Sam68 has been shown to delay LNCaP prostate cancer cells proliferation.[18]

In addition, Sam68 in conjunction with hnRNPA1 influences the choice of the alternative 5' splice sites of Bcl-x regulating pro-survival and apoptotic pathways.[19]

The RNA binding activity of Sam68 is regulated by post-translational modifications such that Sam68 is often referred to as a STAR (Signal Transduction Activator of RNA) protein by which signals from growth factors or soluble tyrosine kinases, such as Src family kinases, act to regulate cellular RNA processes such as alternative splicing.[20] For example, the Sam68-dependent CD44 alternative splicing of exon v5 is regulated by ERK phosphorylation of Sam68[15] and Bcl-x alternative splicing is regulated by the p59fyn-dependent phosphorylation of Sam68.[19]

Sam68 is also downstream of the epidermal growth factor receptor (EGFR),[21] hepatocyte growth factor (HGF)/Met receptor (c-Met),[22] leptin[23] and tumor necrosis factor (TNF) receptors.[24] While the role of Sam68 in these pathways is slowly emerging much remains to be determined. Sam68 has also been shown to re-localize in the cytoplasm near the plasma membrane, where it functions to transport and regulate the translation of certain mRNAs[25] and regulates cell migration.[21]

The many roles of Sam68 in cancer have been reviewed by Bielli et al.,.[26]

Gene knockout studies

Sam68-deficient mice were generated by targeted disruption of exons 4-5 of the sam68 gene, which encode the functional region of the KH domain.[27] The genotypes of the offspring from heterozygote intercrosses exhibited a Mendelian segregation at E18.5. Despite the lack of visible deformity, many of the Sam68-/- pups died at birth of unknown causes.[27] Sam68+/- mice were phenotypically normal and Sam68-/- pups that survived the peri-natal period invariably lived to old age. Sam68-/- mice weighed less than Sam68+/+ littermates and magnetic resonance imaging analysis confirmed that young Sam68-/- mice exhibited a profound reduction in adiposity, although food intake was similar.[13] Moreover, Sam68-/- mice were protected against dietary-induced obesity.[13] Sam68 deficient preadipocytes (3T3-L1 cells) had impaired adipogenesis and Sam68-/- mice had ~45% less adult derived stem cells (ADSCs) in their stromal vascular fraction (SVF) from WAT.[13]

Tumour formation in vivo

Sam68-/- mice did not develop tumors and showed no immunological or other major illnesses. Sam68-/- mice did, however, have difficulty breeding due to male infertility[25][27] and female subfertility.[28] The Sam68-null mice exhibited motor coordination defects and fell from the rotating drum at lower speeds and prematurely compared to the wild-type controls.[29] Sam68-/- mice are protected against age-induced osteoporosis.[27] Using the mammary tumor virus-polyoma middle T-antigen (MMTV-PyMT) mouse model of mammary tumorigenesis, it was shown that reduced Sam68 expression decreases tumor burden and metastasis.[30] Kaplan-Meier curves showed that loss of one sam68 allele (PyMT; Sam68+/-) was associated with a significant delay in the onset of palpable tumors and a significant reduction in tumor multiplicity. These findings suggest that Sam68 is required for PyMT-induced mammary tumorigenesis. The knockdown of Sam68 expression in PyMT-derived mammary cells reduced the number of lung tumor foci in athymic mice, suggesting that Sam68 is also required for mammary tumor metastasis.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000121774 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028790 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wong G, Muller O, Clark R, Conroy L, Moran MF, Polakis P, McCormick F (Jun 1992). "Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62". Cell. 69 (3): 551–8. doi:10.1016/0092-8674(92)90455-L. PMID 1374686. S2CID 30950990.
  6. ^ Lee J, Burr JG (Jan 2000). "Salpalpha and Salpbeta, growth-arresting homologs of Sam68". Gene. 240 (1): 133–47. doi:10.1016/S0378-1119(99)00421-7. PMID 10564820.
  7. ^ "Entrez Gene: KH domain containing, RNA binding, signal transduction associated 1".
  8. ^ Galarneau A, Richard S (May 2009). "The STAR RNA binding proteins GLD-1, QKI, SAM68 and SLM-2 bind bipartite RNA motifs". BMC Mol Biol. 10 (47): 47. doi:10.1186/1471-2199-10-47. PMC 2697983. PMID 19457263.
  9. ^ Lin Q, Taylor SJ, Shalloway D (Oct 1997). "Specificity and determinants of Sam68 RNA binding. Implications for the biological function of K homology domains". J Biol Chem. 272 (43): 27274–27280. doi:10.1074/jbc.272.43.27274. PMID 9341174.
  10. ^ Chawla G, Lin CH, Han A, Shiue L, Ares MJ, Black DL (Jan 2009). "Sam68 regulates a set of alternatively spliced exons during neurogenesis". Mol Cell Biol. 29 (1): 201–13. doi:10.1128/MCB.01349-08. PMC 2612485. PMID 18936165.
  11. ^ a b Pedrotti S, Bielli P, Paronetto MP, Ciccosanti F, Fimia GM, Stamm S, Manley JL, Sette C (Apr 2010). "The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy". EMBO J. 29 (7): 1235–47. doi:10.1038/emboj.2010.19. PMC 2857462. PMID 20186123.
  12. ^ Iijima T, Wu K, Witte H, Hanno-Iijima Y, Glatter T, Richard S, Scheiffele P (Dec 2011). "SAM68 regulates neuronal activity-dependent alternative splicing of neurexin-1". Cell. 147 (7): 1601–14. doi:10.1016/j.cell.2011.11.028. PMC 3246220. PMID 22196734.
  13. ^ a b c d Huot ME, Vogel G, Zabarauskas A, Ngo CT, Coulombe-Huntington J, Majewski J, Richard S (Apr 2012). "The Sam68 STAR RNA-binding protein regulates mTOR alternative splicing during adipogenesis". Mol Cell. 46 (2): 187–99. doi:10.1016/j.molcel.2012.02.007. PMID 22424772.
  14. ^ Cheng C, Sharp PA (Jan 2006). "Regulation of CD44 alternative splicing by SRm160 and its potential role in tumor cell invasion". Mol Cell Biol. 26 (1): 362–70. doi:10.1128/MCB.26.1.362-370.2006. PMC 1317625. PMID 16354706.
  15. ^ a b Matter N, Herrlich P, Konig H (Dec 2002). "Signal-dependent regulation of splicing via phosphorylation of Sam68". Nature. 420 (6916): 691–5. Bibcode:2002Natur.420..691M. doi:10.1038/nature01153. PMID 12478298. S2CID 4349060.
  16. ^ Naor, David; Nedvetzki, Shlomo; Golan, Itshak; Melnik, Lora; Faitelson, Yoram (November 2002). "CD44 in cancer". Critical Reviews in Clinical Laboratory Sciences. 39 (6): 527–579. doi:10.1080/10408360290795574. ISSN 1040-8363. PMID 12484499. S2CID 30019668.
  17. ^ a b Luxton, Hayley J.; Simpson, Benjamin S.; Mills, Ian G.; Brindle, Nicola R.; Ahmed, Zeba; Stavrinides, Vasilis; Heavey, Susan; Stamm, Stefan; Whitaker, Hayley C. (2019-08-23). "The Oncogene Metadherin Interacts with the Known Splicing Proteins YTHDC1, Sam68 and T-STAR and Plays a Novel Role in Alternative mRNA Splicing". Cancers. 11 (9): 1233. doi:10.3390/cancers11091233. ISSN 2072-6694. PMC 6770463. PMID 31450747.
  18. ^ Busà R, Paronetto MP, Farini D, Pierantozzi E, Botti F, Angelini DF, Attisani F, Vespasiani G, Sette C (Jun 2007). "The RNA-binding protein Sam68 contributes to proliferation and survival of human prostate cancer cells". Oncogene. 26 (30): 4372–82. doi:10.1038/sj.onc.1210224. PMID 17237817.
  19. ^ a b Paronetto MP, Achsel T, Massiello A, Chalfant CE, Sette C (Mar 2007). "The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x". J Cell Biol. 176 (7): 929–39. doi:10.1083/jcb.200701005. PMC 2064079. PMID 17371836.
  20. ^ Richard S (2010). "Reaching for the STARs: Linking RNA Binding Proteins to Diseases". Post-Transcriptional Regulation by STAR Proteins. Advances in Experimental Medicine and Biology. Vol. 693. pp. 142–57. doi:10.1007/978-1-4419-7005-3_10. ISBN 978-1-4419-7004-6. PMID 21189691.
  21. ^ a b Huot ME, Vogel G, Richard S (Nov 2009). "Identification of a Sam68 ribonucleoprotein complex regulated by epidermal growth factor". J Biol Chem. 284 (46): 31903–13. doi:10.1074/jbc.M109.018465. PMC 2797261. PMID 19762470.
  22. ^ Locatelli A, Lange CA (Jun 2011). "Met receptors induce Sam68-dependent cell migration by activation of alternate extracellular signal-regulated kinase family members". J Biol Chem. 286 (24): 21062–72. doi:10.1074/jbc.M110.211409. PMC 3122167. PMID 21489997.
  23. ^ Maroni P, Citterio L, Piccoletti R, Bendinelli P (Oct 2009). "Sam68 and ERKs regulate leptin-induced expression of OB-Rb mRNA in C2C12 myotubes" (PDF). Mol Cell Endocrinol. 309 (1–2): 26–31. doi:10.1016/j.mce.2009.05.021. PMID 19524014. S2CID 28228732.
  24. ^ Ramakrishnan P, Baltimore D (Jul 2011). "Sam68 is required for both NF-κB activation and apoptosis signaling by the TNF receptor". Mol Cell. 43 (2): 167–79. doi:10.1016/j.molcel.2011.05.007. PMC 3142289. PMID 21620750.
  25. ^ a b Paronetto MP, Messina V, Bianchi E, Barchi M, Vogel G, Moretti C, Palombi F, Stefanini M, Geremia R, Richard S, Sette C (Apr 2009). "Sam68 regulates translation of target mRNAs in male germ cells, necessary for mouse spermatogenesis". J Cell Biol. 185 (2): 235–49. doi:10.1083/jcb.200811138. PMC 2700383. PMID 19380878.
  26. ^ Bielli P, Busà R, Paronetto MP, Sette C (Jul 2011). "The RNA-binding protein Sam68 is a multifunctional player in human cancer" (PDF). Endocr Relat Cancer. 18 (4): R91–R102. doi:10.1530/ERC-11-0041. hdl:2108/88068. PMID 21565971.
  27. ^ a b c d Richard S, Torabi N, Franco GV, Tremblay GA, Chen T, Vogel G, Morel M, Cleroux P, Forget-Richard A, Komarova S, Tremblay ML, Li W, Li A, Gao YJ, Henderson JE (Dec 2005). "Ablation of the Sam68 RNA binding protein protects mice from age-related bone loss". PLOS Genet. 1 (6): e74. doi:10.1371/journal.pgen.0010074. PMC 1315279. PMID 16362077.
  28. ^ Bianchi E, Barbagallo F, Valeri C, Geremia R, Salustri A, De Felici M, Sette C (Dec 2010). "Ablation of the Sam68 gene impairs female fertility and gonadotropin-dependent follicle development". Hum Mol Genet. 19 (24): 4886–94. doi:10.1093/hmg/ddq422. PMID 20881015.
  29. ^ Lukong KE, Richard S (Jun 2008). "Motor coordination defects in mice deficient for the Sam68 RNA-binding protein". Behav Brain Res. 189 (2): 357–63. doi:10.1016/j.bbr.2008.01.010. PMID 18325609. S2CID 37887832.
  30. ^ Richard S, Vogel G, Huot ME, Guo T, Muller WJ, Lukong KE (Jan 2008). "Sam68 haploinsufficiency delays onset of mammary tumorigenesis and metastasis". Oncogene. 27 (4): 548–56. doi:10.1038/sj.onc.1210652. PMID 17621265.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Read other articles:

Perpustakaan John C. Hodges

Bangunan dilihat dari selatan. Kentaur dari Volos, dipamerkan di lantai dua perpustakaan. Perpustakaan John C. Hodges adalah perpustakaan utama di Universitas Tennessee. Perpustakaan ini dibuka pada tahun 1969 dan memiliki lebih dari 3 juta sumber daya komputer, periodik, dan volume perpustakaan.[1] Koleksi buku langkanya berjumlah sekitar 51.000, dan yang tertua berasal dari tahun 1481 M.[2] Perpustakaan ini termasuk dalam perpustakaan terbaik di Amerika Serikat menurut Chron...

 

The Visitors (installation)

2012 art installation by Ragnar Kjartansson This article is about The Visitors, an installation art piece by Ragnar Kjartansson. For other uses, see Visitor (disambiguation). The VisitorsArtistRagnar KjartanssonYear2012TypeInstallation art; video artLocationShown in several places, including The Broad and The Guggenheim The Visitors is a 2012 installation and video art piece created by Ragnar Kjartansson.[1] Kjartansson named the piece for The Visitors, the final album by the Swedish ...

 

Gosbank

Central and only bank of the Soviet Union State Bank of the USSRГосударственный банк СССРHeadquarters12 Neglinnaya str., Moscow, Soviet UnionEstablished1922 (1922)Dissolved26 December 1991; 32 years ago (1991-12-26)Central bank of Soviet UnionCurrencySoviet rubleSUR (ISO 4217)Preceded byState Bank of the RSFSR State Bank of the Russian Empire (1860–1917/1922)Succeeded byBank of RussiaNational Bank of Ukraine (1991–present) ...

Синелобый амазон

Синелобый амазон Научная классификация Домен:ЭукариотыЦарство:ЖивотныеПодцарство:ЭуметазоиБез ранга:Двусторонне-симметричныеБез ранга:ВторичноротыеТип:ХордовыеПодтип:ПозвоночныеИнфратип:ЧелюстноротыеНадкласс:ЧетвероногиеКлада:АмниотыКлада:ЗавропсидыКласс:Пт�...

 

Pentagon Papers (film)

Pour les articles homonymes, voir Paper, Pentagon Papers et Post. Pentagon Papers Katharine Graham [1917-2001], éditrice du Washington Post, invitée à une réunion de la Dutch Newspaper Press (NDP) Données clés Titre québécois Le Post Titre original The Post Réalisation Steven Spielberg Scénario Liz HannahJosh Singer Musique John Williams Acteurs principaux Meryl StreepTom Hanks Sociétés de production Fox Searchlight PicturesAmblin PartnersAmblin EntertainmentPascal PicturesStar T...

 

Big Fish

Big Fish Indeks kartuSutradaraTim BurtonProtagonisEwan McGregorAlbert FinneyBilly CrudupJessica LangeMarion CotillardAlison LohmanProduksi seni pertunjukanDan JinksBruce CohenRichard D. ZanuckPerancang produksiDennis Gassner NaskahJohn AugustMusikDanny ElfmanFotografiPhilippe Rousselot Penyuntingan filmChris Lebenzon BusanaColleen Atwood Tata riasArjen Tuiten Rumah produksiColumbia Pictures DistributorColumbia PicturesPenampilan perdana 10 Desember 2003 (2003-12-10) Durasi126 menitBahas...

Lindsay Whalen

Questa voce sugli argomenti cestisti statunitensi e allenatori di pallacanestro statunitensi è solo un abbozzo. Contribuisci a migliorarla secondo le convenzioni di Wikipedia. Segui i suggerimenti dei progetti di riferimento 1, 2. Lindsay Whalen Lindsay Whalen nel 2018 Nazionalità  Stati Uniti Altezza 173 cm Peso 68 kg Pallacanestro Ruolo Allenatrice (ex playmaker) Termine carriera 2018 - giocatrice Hall of fame Naismith Hall of Fame (2022)Women's Basketball Hall of Fame...

 

Biblioteca Nacional de España

Biblioteca Nacional de EspañaLokasiMadrid, SpanyolDidirikan1712; 311 tahun lalu (1712)Landasan hukumSurat Keputusan 1581/1991pada tanggal 31 Oktober.CollectionBarang yang dikoleksiBuku, jurnal, surat kabar, majalah, rekaman suara dan musik, paten, basis data, peta, prangko, grafis, gambar dan naskahUkuran26,000,000 item, termasuk 15,000,000 buku dan bahan cetak lainnya, 30,000 manuskrip, 143,000 surat kabar dan serial, 4,500,000 bahan grafis, 510,000 skor musik, dllPerpustakaan depositY...

 

Talkradio

Not to be confused with the radio format talk radio. For the sister station formerly known as Talk Radio, see Talksport. Radio stationTalkRadioBroadcast areaUnited KingdomFrequencyDAB+: 11A Sound DigitalProgrammingLanguage(s)EnglishFormatTalk radioOwnershipOwnerNews UK Broadcasting Ltd(News UK)Sister stationsTalksportTalksport 2Times RadioVirgin Radio UKVirgin Radio AnthemsVirgin Radio ChilledVirgin Radio 80s PlusHistoryFirst air date21 March 2016; 8 years ago (2016-03-21)Te...

Perdana Menteri Korea Utara

Perdana Menteri Republik Demokratik Rakyat KoreaLambang negaraPetahanaKim Tok-hunsejak 13 Agustus 2020Pejabat perdanaKim Il-sungDibentuk9 September 1948 Perdana Menteri Korea Utara (resmi Perdana Menteri Kabinet Republik Demokratik Rakyat Korea) adalah kepala pemerintahan Korea Utara. Fungsi dan sejarah Perdana menteri memimpin aktivitas Pemerintah dan mewakili itu. Perdana menteri tidak memiliki kekuasaan eksekutif yang nyata, karena kebijakan utama yang ditetapkan oleh Komite Sentral P...

 

Ágios Dimítrios - Aléxandros Panagoúlis (métro d'Athènes)

Ágios Dimítrios - Aléxandros Panagoúlis Le quai central de la station. Localisation Pays Grèce Ville Ágios Dimítrios (Athènes-Sud) Coordonnéesgéographiques 37° 56′ 26″ nord, 23° 44′ 27″ est Géolocalisation sur la carte : Grèce Caractéristiques Position parrapport au sol souterrain Quais 1 central Historique Mise en service 5 juin 2004 Gestion et exploitation Propriétaire Attiko Metro SA Exploitant STASY SA Ligne(s) Dáfni Ilioúpoli ...

 

Opération Manta

Cet article est une ébauche concernant un conflit armé. Vous pouvez partager vos connaissances en l’améliorant (comment ?) selon les recommandations des projets correspondants. Opération MantaPrésentationType Opération militairePartie de Conflit tchado-libyenmodifier - modifier le code - modifier Wikidata L'opération Manta est une opération militaire française qui s'est déroulée au Tchad d'août 1983 à novembre 1984 en soutien au Tchad dans le cadre du conflit tchado-libye...

Горки (усадьба)

УсадьбаБольшие Горки 55°30′17″ с. ш. 37°45′52″ в. д.HGЯO Страна  Россия Местоположение Горки Ленинские Статус  Объект культурного наследия народов РФ федерального значения. Рег. № 501420777940006 (ЕГРОКН). Объект № 5010232000 (БД Викигида)  Медиафайлы на Викискладе Об �...

 

世界政區索引

此條目可能包含不适用或被曲解的引用资料，部分内容的准确性无法被证實。 (2023年1月5日)请协助校核其中的错误以改善这篇条目。详情请参见条目的讨论页。 各国相关 主題列表 索引 国内生产总值 石油储量 国防预算 武装部队（军事） 官方语言 人口統計 人口密度 生育率 出生率 死亡率 自杀率 谋杀率 失业率 储蓄率 识字率 出口额 进口额 煤产量 发电量 监禁率 死刑 国债 ...

 

محير الترمس

  لمعانٍ أخرى، طالع ترمس (توضيح). 27°21′34″N 43°36′14″E / 27.359532°N 43.603930°E / 27.359532; 43.603930 محير الترمس العلم الشعار تقسيم إداري البلد  السعودية المنطقة الإدارية منطقة القصيم المسؤولون رئيس المركز نايف بن فالح بن نايف الغازي.[1] خصائص جغرافية إحداثيات 27°21′34″N 43...

Osami Nagano

Osami NaganoOsami Nagano mengenakan seragam Wakil LaksamanaNama asli永野 修身Lahir(1880-06-15)15 Juni 1880Kōchi, Prefektur Kōchi, JepangMeninggal5 Januari 1947(1947-01-05) (umur 66)[1]Tokyo, JepangPengabdianKekaisaran JepangDinas/cabangAngkatan Laut Kekaisaran JepangLama dinas1900 -1947PangkatMarsekal Laksamana Laksamana Armada Staf Jenderal Komandan Hirado Divisi Intelijensi NGS ke-3, Divisi Pertempuran ke-3, Armada Ekspedisi Tiongkok ke-1, Staf Jenderal Angkatan Laut...

 

Branko Ivanković

Croatian footballer and manager Branko Ivanković Ivanković as Persepolis manager in 2019Personal informationDate of birth (1954-02-28) 28 February 1954 (age 70)Place of birth Varaždin, PR Croatia, YugoslaviaHeight 1.81 m (5 ft 11 in)Position(s) Attacking midfielderTeam informationCurrent team China (manager)Senior career*Years Team Apps (Gls)1979–1990 Varteks 269 (83)Managerial career1991–1995 Varteks1995–1996 Segesta1996–1998 Rijeka1998–1999 Croatia (assistan...

 

Siamese Expeditionary Forces

Siamese military unit in World War I Siamese Expeditionary ForcesSiamese Expeditionary Forces at the 1919 Paris Victory ParadeActive1917–1919Disbanded1919, after the signing of the Treaty of VersaillesCountryKingdom of SiamAllegianceTriple EntenteTypeLogistics supportArmy Aviation regimentMedical supportRoleCombined armsExpeditionary warfareSize1,284 menEngagements World War I Western Front Second Battle of the Marne Hundred Days Offensive Meuse-Argonne Offensive DecorationsCroix de guerre ...

Jawi Peranakan

Ethnic group of Malaysia and Singapore Ethnic group Jawi Peranakanجاوي ڤرانقن‎Regions with significant populationsMalaysia and SingaporeLanguagesMalayReligionSunni IslamRelated ethnic groupsMalaysian Indians · Indian Singaporeans · Malay The Jawi Peranakan (Jawi: جاوي ڤرانقن‎) is an ethnic group found primarily within the Malaysian state of Penang and in Singapore, both regions were part of the historical Straits Settlements where th...

 

Judiciary Act of 1789

This article includes a list of references, related reading, or external links, but its sources remain unclear because it lacks inline citations. Please help improve this article by introducing more precise citations. (September 2022) (Learn how and when to remove this message)United States law establishing the federal court system Judiciary Act of 1789Long titleAn Act to establish the Judicial Courts of the United StatesNicknamesestablishment of the federal judiciaryEnacted bythe 1st Un...