Kurpeikis played college football at Penn State, finishing his career with 172 tackles, 17 sacks and 43 stops for losses. He also twice earned Academic All-Big Ten honors and was included in the second-team All-Big Ten in 2000.
Kurpeikis served as an assistant coach with the State College ninth grade Little Lions football team in State College, Pennsylvania, leading the team to a 6–2 record overall. In a 2005 interview with Mark Harrington, Justin exclaimed that "The advice I want to give to everyone out there, "No matter up or down, you have to constantly strive for more and more and never be satisfied. People have their backs against the wall and in tough situations and they have two choices: cower or come out swinging... I would advise you all to come out swinging!"
^Doerschuk, Steve (August 17, 2007). "Browns vs. Lions at a glance". Watertown TAB. Archived from the original on February 12, 2020. Retrieved February 12, 2020. Lions defensive end Justin Kurpeikis was on Cleveland's 53-man roster in 2005.