A three-star recruit, Ezirim committed to play college football for the Eastern Kentucky Colonels; he had other offers from larger schools including the Cincinnati Bearcats, but declined as he, according to The Athletic, "didn't want anything to do with the offensive line", and wanted to be sure he would not play there.[1] He enrolled at Eastern Kentucky in 2019 and also was a member of the school's indoor track team for a time.[1] He played in 10 games as a true freshman in 2019, recording three tackles, and then played in six games with nine tackles in 2020.[2]
In 2021, Ezirim was told he might have better opportunities if he moved to the offensive line, and, considering that he had a mere 12 tackles and no starts in his first two years on defense, he accepted the offer.[3] He appeared in five games as a backup that year, but then became a top player at right tackle in his last two seasons.[2][4] He appeared in all 12 games in 2022 and was chosen fourth-team All-ASUN.[5][6] In his final year, 2023, he started 11 games and was named first-team All-United Athletic Conference (UAC) as well as a third-team FCSAll-American by the Associated Press (AP).[4] He was invited to the East–West Shrine Bowl and to the NFL Scouting Combine.[7][8]
Ezirim was selected in the seventh round (239th overall) of the 2024 NFL draft by the New Orleans Saints.[11] He was waived on August 27, and re-signed to the practice squad.[12][13]