On December 9, 2010, the Pirates selected Rodriguez with the first overall pick of the 2010 Rule 5 draft.[1] Under the rules regarding Rule 5 players, Rodriguez had to stay on the team's major league roster for the entire 2011 season, or be offered back to the Indians.
On March 27, 2011. the Pirates announced that Rodriguez would be on the team's Opening Day roster, after infielder Pedro Ciriaco was optioned to the Triple–A Indianapolis Indians. Pirates general manager Neal Huntington stated Rodriguez proved during spring training that he is adept enough defensively to hold his own in the big leagues. Huntington also added that "[Rodriguez] is not your typical Rule 5 guy. He's a little better-equipped to handle the major league environment than a typical Rule 5 guy."[2] The announcement of Rodriguez being named to the Pirates Opening Day roster came moments after he and Ciriaco helped the team defeat the Tampa Bay Rays in a spring training game by scoring on a throwing error in the bottom of the ninth inning to give the Pirates a 5-4 victory.[3] He was designated for assignment on April 22 to make room for Brandon Wood on the roster.[4] The Cleveland Indians reacquired him on April 29 and assigned him to Triple–A Columbus.[5] However, he was traded back to Pittsburgh on June 21 for cash considerations.[6]
In the Pirates minor league system, he played for the Indianapolis Indians of the IL and the Altoona Curve of the EL. In the 2011 season he played for Pittsburgh, Indianapolis, Altoona, and Columbus.
New York Mets
On March 29, 2012, Rodriguez signed a minor league deal with the New York Mets. Rodriguez began the year with the Binghamton Mets of the EL.[7] He was named EL Player of the Week on April 23.[8]
Miami Marlins
On January 27, 2014, Rodriguez signed a minor league contract with the Miami Marlins organization and was assigned to the Triple-A New Orleans Zephyrs to begin the season.
New York Mets (second stint)
On March 8, 2015, Rodriguez signed a minor league deal with the New York Mets. He was assigned to the Triple–A Las Vegas 51s. On April 2, 2015 he was demoted to the AA Binghamton Mets.
Oakland Athletics
On November 25, 2015, Rodriguez signed a minor league contract with the Oakland Athletics.[9] He began the 2016 season with the Double-A Midland RockHounds, but was promoted to the Triple-A Nashville Sounds in late April. In 88 games between the two affiliates, Rodriguez hit .263/.381/.420 with nine home runs and 53 RBI. He elected free agency following the season on November 7, 2016.[10]
On November 8, 2016, Rodriguez re–signed with Oakland on a new minor league contract.[11] He was released during spring training.[12]
New York Mets (third stint)
On April 3, 2017, Rodriguez signed a minor league deal with the New York Mets and was assigned to the Triple–A Las Vegas 51s. In 106 games for Las Vegas, Rodriguez hit .242/.299/.395 with 12 home runs and 44 RBI. He elected free agency following the season on November 6.[13]
Toros de Tijuana
On March 20, 2018, Rodriguez signed with the Toros de Tijuana of the Mexican Baseball League. In 18 games he hit .160/.276/.200 with 0 home runs and 2 RBIs with 1 stolen base.
Tecolotes de los Dos Laredos
On May 3, 2018, Rodriguez was traded to the Tecolotes de los Dos Laredos of the Mexican Baseball League. He appeared in 66 games for the club, collecting 61 hits and 9 home runs. In 2019, Rodriguez slashed .312/.385/.526 with 22 home runs and 88 RBI in 117 games for the team. Rodriguez did not play in a game in 2020 due to the cancellation of the Mexican League season because of the COVID-19 pandemic.[14]
In 2021, Rodriguez played in 53 games for Dos Laredos, batting .230/.302/.410 with 6 home runs and 24 RBI. For the 2022 season, he made 77 appearances for the Tecolotes, hitting .224/.303/.354 with 7 home runs and 35 RBI.
Mariachis de Guadalajara
On February 11, 2023, Rodriguez signed with the Mariachis de Guadalajara of the Mexican League.[15] In 74 games for Guadalajara, Rodriguez batted .300/.368/.463 with 9 home runs and 44 RBI.