In 2009, Schneider-Ammann became a member of the newly-established FDP.The Liberals. In the 2010 election, he was elected to the Swiss Federal Council as Hans-Rudolf Merz's successor.[5] He took office on 1 November 2010 as the head of the Federal Department of Economic Affairs, which became the Federal Department of Economic Affairs, Education and Research in 2013.[6] He had previously announced his intention to step down from his corporate responsibilities as well as various board memberships if elected.[1]
In 2015, he took office as Vice President of Switzerland under President Simonetta Sommaruga. He was inaugurated as President of the Swiss Confederation on 1 January 2016 along Vice President Doris Leuthard. In March 2016, he became an Internet meme after a speech on laughter that many deemed sad.[7] On 1 June 2016, as President of Switzerland, Schneider-Ammann was present at the official opening of the Gotthard Base Tunnel, which became the world's longest railway tunnel, alongside German Chancellor Angela Merkel, French President François Hollande and Italian Prime Minister Matteo Renzi among others.[8]
On 31 December 2018, Schneider-Ammann left the Federal Council; he was replaced by Karin Keller-Sutter on 1 January 2019.