West was signed by the New Orleans Saints, only to be waived during final cuts on August 30, 2008. He was subsequently re-signed to the team's practice squad.
Joe West caught his first CFL touchdown in the Stampeders' 17–10 win over the Saskatchewan Roughriders on August 25, 2012.[5][6] Calgary head coach John Hufnagel commented on West after the game: "He executed his assignments well. That's exactly what we got him for."[7] West would finish his first season in the CFL with 24 catches for 353 yards and 2 touchdowns.
West would start in 6 regular season games in the 2013 season totaling 277 yards on 19 pass receptions, with 3 touchdowns. He also added 3 receptions for 101 yards and a touchdown in the Western Final against Saskatchewan. Joe West missed 12 games of the season with a shoulder injury. On January 17, 2014, West signed a contract extension with the Calgary Stampeders.[8]