Joachim Boldt

Joachim Boldt
Born (1954-09-29) 29 September 1954 (age 70)
NationalityGerman
Known forFalsifying scientific data
Scientific career
FieldsAnesthesiology
InstitutionsLudwigshafen Hospital
University of Giessen

Joachim Boldt (born 29 September 1954[1]) is a German anesthesiologist who fabricated or falsified data, including those reporting clinical trial results.[2]

Medical research fabrication

Boldt was previously considered to be a leading researcher of medicinal colloids. He was an advocate for the use of colloidal hydroxyethyl starch (HES) to boost blood pressure during surgery.[3] However, a meta-analysis of trials that excluded Boldt's fabricated data found that the intravenous use of hydroxyethyl starch is associated with a significant increased risk of death and acute kidney injury compared with other resuscitation solutions.[4] He was stripped of his professorship and came under criminal investigation for possible forgery of up to 90 research studies.[5]

The editors of 16 different scientific journals, including Anesthesia & Analgesia, Anaesthesia, the European Journal of Anaesthesiology, and the British Journal of Anaesthesia, allege that 89 of 102 studies published by Boldt contained research without proper institutional review board approval.[6]

On 10 November 2010 Boldt was suspended from Klinikum Ludwigshafen, a hospital in Ludwigshafen, Germany, for a scientific publication in Anesthesia & Analgesia with insufficient background research. His field of research and the publications were related to hydroxyethyl starch.[7] Some 90 studies he published were being reviewed by medical authorities in 2011.[8]

In February 2011, Boldt was stripped of his title of professor at the University of Giessen for failing to teach, and the university investigated possible charges of scientific misconduct.[9] His case was described as "possibly the biggest medical research scandal since Andrew Wakefield was struck off in 2010 for falsely claiming to have proved a link between the MMR vaccine and autism".[5]

In August 2012, the hospital released the results of the investigation: while it did not find that any patients were harmed, "in a large number of the studies investigated, the conduct of research failed to meet required standards. False data were published in at least 10 of the 91 articles examined, including, for instance, data on patient numbers/study groups as well as data on the timing of measurements".[10]

On 20 February 2013, JAMA published a meta-analysis on HES in critically ill patients.[4] Boldt had seven studies from the 1990s that had not yet been retracted. If Boldt's papers were included in the analysis no increase in mortality was apparent; but if they were excluded, mortality was seen to increase significantly with use of HES. The Boldt studies, but no others, showed an improvement with HES; all other studies showed significant risks with no benefits. It is considered that his fraudulent studies caused harm and risk to critically ill patients.[11]

An overview of the challenges that this fraud presented for the meta-analysts was published in 2013. The fraud included double publication of studies, manipulating demographic and outcome data to conceal double publication, and showing better results for a drug being tested.[12]

By 2017, 96 of Boldt's papers had been retracted.[13] In October 2018, a review highlighted additional retractions, dating back to 1986, demonstrating persistent fraud since the start of Boldt's career. Statistical analyses found that it was likely that many fraudulent papers from Boldt remained, and recommended that editors should take action.[14] However, some of Boldt's papers were not retracted until 2023.[15] As of August 2023, 199 of Boldt's research publications had been retracted[2]—a record for the author with the most retractions.[16] This count has increased to 210 retractions as of May 2024.[17]

See also

References

  1. ^ "Curriculum Vitae - Professor Dr. med. Joachim Boldt". Gemeinsame Presseveranstaltung [Joint press event] (PDF) (Report) (in German). Deutschen Gesellschaft für Chirurgie (DGCH) und der Deutschen Gesellschaft für Anästhesiologie und Intensivmedizin (DGAI). p. 17. Archived from the original (PDF) on 2012-03-19.
  2. ^ a b "Search for "Joachim Boldt"". Retraction Watch Database. Center for Scientific Integrity. 50 Items Displayed Out of 199 Item(s) Found (search on 9 August 2023)
  3. ^ Wise, Jacqui (2013-03-19). "Boldt: the great pretender". BMJ. 346: f1738. doi:10.1136/bmj.f1738. ISSN 1756-1833. PMID 23512099. S2CID 38003087.
  4. ^ a b Zarychanski, Ryan; Abou-Setta, Ahmed M.; Turgeon, Alexis F.; Houston, Brett L.; McIntyre, Lauralyn; Marshall, John C.; Fergusson, Dean A. (2013). "Association of Hydroxyethyl Starch Administration with Mortality and Acute Kidney Injury in Critically Ill Patients Requiring Volume Resuscitation". JAMA. 309 (7): 678–88. doi:10.1001/jama.2013.430. PMID 23423413.
  5. ^ a b Blake, Heidi; Watt, Holly; Winnett, Robert (3 March 2011). "Millions of surgery patients at risk in drug research fraud scandal". The Daily Telegraph. Archived from the original on 5 March 2011.
  6. ^ "Medical journals retract 'unethical' research", Kate Kelland, Reuters, March 4, 2011
  7. ^ Informationsdienst Wissenschaft: "DGAI: Wissenschaftliches Fehlverhalten in der Anästhesie inakzeptabel" 2010-11-26 (retrieved 2011-03-04) German
  8. ^ Blake, Heidi (3 March 2011). "Joachim Boldt profile: a glittering career built on charisma and charm". The Daily Telegraph. Archived from the original on 7 March 2011.
  9. ^ Giessen University: "Akademische Bezeichnung aberkannt" 2011-02-15 (retrieved: 2011-03-04) (in German)
  10. ^ "Hospital Presents Results of Final Report: Committee Completes Investigation in the Case of Dr Boldt". klilu.de (Klinikum Ludwigshafen) (Press release). Akademisches Lehrkrankenhaus der Johannes Gutenberg-Universität Mainz. 18 October 2012. Archived from the original on 22 October 2012.
  11. ^ Antonelli, Massimo; Sandroni, Claudio (2013). "Hydroxyethyl Starch for Intravenous Volume Replacement". JAMA. 309 (7): 723–4. doi:10.1001/jama.2013.851. PMID 23423420.
  12. ^ Wilkes, Mahlon M.; Navickis, Roberta J. (2013). "The Boldt affair: a quandary for meta-analysts". Anesthesiology News. 39 (4): 8–9. Archived from the original on 2015-04-25.
  13. ^ "The Retraction Watch Leaderboard". 2015-06-16.
  14. ^ Wiedermann, Christian J.; Joannidis, Michael (2018). "The Boldt scandal still in need of action: The example of colloids 10 years after initial suspicion of fraud". Intensive Care Medicine. 44 (10): 1735–1737. doi:10.1007/s00134-018-5289-3. PMC 7572333. PMID 29968012.
  15. ^ Oransky, Ivan (9 August 2023). "There's far more scientific fraud than anyone wants to admit". The Guardian.
  16. ^ "The new retraction record holder is a German anesthesiologist [Joachim Boldt], with 184". Retraction Watch. 2023-07-12. Retrieved 2023-08-03.
  17. ^ "A retraction milestone: 200 for one author - Retraction Watch". Retraction Watch. 2024-05-23. Retrieved 2024-05-23.

Read other articles:

Zenit

Disambiguazione – Zenith rimanda qui. Se stai cercando altri significati, vedi Zenit (disambigua) o Zenith (disambigua). La sfera celeste: zenit e nadir in evidenza. In beige, il piano dell'orizzonte astronomico; in azzurro l'emisfero celeste visibile, in blu quello invisibile; C è il centro della Terra e della sfera celeste, mentre O è l'osservatore terrestre. Lo zenit[1] nell'astronomia osservativa indica il punto di intersezione tra la retta perpendicolare al piano...

 

 

Guerre rivoluzionarie francesi

Guerre rivoluzionarie francesiIl generale Napoleone Bonaparte guida l'assalto al ponte di ArcoleData1792 – 1802 LuogoEuropa, Egitto, Medio oriente, Oceano Atlantico, Caraibi EsitoVittoria francese, sfociata nei trattati di Lunéville e Amiens Schieramenti Gran Bretagna Austria Impero russo Prussia Regno di Napoli Regno di Sicilia Regno di Sardegna Regno di Corsica[1] Impero ottomano Portogallo Province Unite (fino al 1795) Spagna (fino al 1796) Realisti francesi Regno di Franci...

 

 

Veramark Technologies

Veramark Technologies, Inc.Company typePublicTraded asOTCQB: VERAIndustrySoftware and managed services for Telecom Expense ManagementPredecessorMOSCOM CorporationFoundedJanuary 1983FounderAlbert J. MontevecchioSuccessorCaleroHeadquartersHenrietta, New YorkArea servedUnited States, CanadaKey peopleTony Mazzullo, President and CEOProductsVeraSMART Telecom Expense Management SuiteVeraSMART Call Accounting SoftwareServicesManaged and professional Telecom Expense Management servicesRevenue US$13.1...

Nanda (half-brother of Buddha)

Son of Suddhodan ShakyaThis article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Nanda half-brother of Buddha – news · newspapers · books · scholar · JSTOR (July 2021) (Learn how and when to remove this template message) For his sister, see Nanda (Buddhist nun). Most Venerable Nanda TheraNanda Shakya, enticed by ...

 

 

Brass Tacks (Pakistani TV program)

This article relies excessively on references to primary sources. Please improve this article by adding secondary or tertiary sources. Find sources: Brass Tacks Pakistani TV program – news · newspapers · books · scholar · JSTOR (May 2008) (Learn how and when to remove this template message) Pakistani TV series or programme Brass TacksGenreNewsStarringZaid Zaman HamidCountry of originPakistanOriginal releaseNetworkNews One (Pakistani TV channel) B...

 

 

2017 World Junior Ice Hockey Championships

Under-20 ice hockey championship held in Canada 2017 IIHF World Junior ChampionshipTournament detailsHost country CanadaCityMontreal, TorontoVenue(s)Bell CentreAir Canada Centre (in 2 host cities)DatesDecember 26, 2016 – January 5, 2017Teams10Final positionsChampions  United States (4th title)Runner-up  CanadaThird place  RussiaFourth place SwedenTournament statisticsGames played30Goals scored183 (6.1 per game)Attendance257,882...

Douglas Osheroff

American physicist Douglas OsheroffOsheroff in 2011BornDouglas Dean Osheroff (1945-08-01) August 1, 1945 (age 78)Aberdeen, Washington, U.S.NationalityAmericanCitizenshipUnited StatesAlma materCalifornia Institute of Technology (B.S.), Cornell University (Ph.D.)Known forDiscovering superfluidity in Helium-3Spouse Phyllis Liu ​(m. 1970)​AwardsNobel Prize in Physics (1996) Simon Memorial Prize (1976)Buckley Prize (1981) MacArthur Fellowship Program (19...

 

 

Філософія

Частина серії проФілософіяLeft to right: Plato, Kant, Nietzsche, Buddha, Confucius, AverroesПлатонКантНіцшеБуддаКонфуційАверроес Філософи Епістемологи Естетики Етики Логіки Метафізики Соціально-політичні філософи Традиції Аналітична Арістотелівська Африканська Близькосхідна іранська Буддій�...

 

 

La Bayadère

Ballet This article includes a list of general references, but it lacks sufficient corresponding inline citations. Please help to improve this article by introducing more precise citations. (October 2014) (Learn how and when to remove this message) Marius Petipa's final revival of La Bayadère, with the stage of the Mariinsky Theatre shown in the scene The Kingdom of the Shades. In the center is Mathilde Kschessinskaya as Nikiya and Pavel Gerdt as Solor. The three soloist shades are seen knee...

Dependent and independent variables

For dependent and independent random variables, see Independence (probability theory). Concept in mathematical modeling, statistical modeling and experimental sciences A variable is considered dependent if it depends on an independent variable. Dependent variables are studied under the supposition or demand that they depend, by some law or rule (e.g., by a mathematical function), on the values of other variables. Independent variables, in turn, are not seen as depending on any other variable ...

 

 

Formaldoxime

Formaldoxime Names Preferred IUPAC name N-Hydroxymethanimine Identifiers CAS Number 75-17-2 3D model (JSmol) Interactive image ChemSpider 6110 ECHA InfoCard 100.000.769 EC Number 200-845-7 PubChem CID 6350 UNII 420JFM0Z1Q CompTox Dashboard (EPA) DTXSID9058785 InChI InChI=1S/CH3NO/c1-2-3/h3H,1H2Key: SQDFHQJTAWCFIB-UHFFFAOYSA-N SMILES C=NO Properties Chemical formula H2C=N−OH Molar mass 45.041 g·mol−1 Appearance colorless liquid Melting point 2.5 °C (36.5 ...

 

 

فوكينو (مقاطعة بريانسك)

فوكينو    علم شعار الاسم الرسمي (بالروسية: Цементный Завод)‏  الإحداثيات 53°27′00″N 34°25′00″E / 53.45°N 34.416666666667°E / 53.45; 34.416666666667   تاريخ التأسيس 1899  تقسيم إداري  البلد روسيا[1]  خصائص جغرافية ارتفاع 190 متر  عدد السكان  عدد السكان 2200 (1926)2600 (1931...

Velluvili

1978 Indian filmVelluviliCD CoverDirected byK. G. RajasekharanWritten byPappanamkodu LakshmananProduced byT. V. VijayaraghavanStarringSomanJayabharathiCinematographyP. S. NivasEdited byV. P. KrishnanMusic byM. S. ViswanathanLyrics:Bichu ThirumalaProductioncompanyChandhamani FilmsRelease date 24 February 1978 (1978-02-24) CountryIndiaLanguageMalayalam Velluvili (English: Challenge) is a 1978 Malayalam film, starring Soman and Jayabharathi in the lead roles. It marked the direct...

 

 

樓亦文

樓亦文个人资料字字以文出生？年？月？日逝世？年？月？日 樓亦文（？—？），字以文。浙江省餘姚縣人[1]，民國37年（1948年）在廣西省選區當選第一屆立法委員。 生平[2] 北平女子師範大學畢業，留學法國[3] 全國學總北京代表[4] 民國20年4月20日，在杭州與黃研真結為夫婦 民國38年，當選立法委員，曾出席第一屆第一會期教育文化委員會、社會委�...

 

 

Johann Gottlieb Fichte

Johann Gottlieb Fichte Johann Gottlieb Fichte (* 19. Mai 1762 in Rammenau, Kurfürstentum Sachsen; † 29. Januar 1814 in Berlin, Königreich Preußen) war ein deutscher Erzieher und Philosoph sowie Professor der Philosophie. Er gilt neben Friedrich Wilhelm Joseph Schelling und Georg Wilhelm Friedrich Hegel als bedeutendster Vertreter des Deutschen Idealismus. Inhaltsverzeichnis 1 Leben 1.1 Jugendzeit 1.2 Übergang zur Philosophie 1.3 Tod 2 Fichtes Grundlage der gesamten Wissenschaftslehre 3 ...

إجهاض تلقائي

الاجهاض التلقائي تظهر الصورة جنين داخل الرحم عمره 6 أسابيع بعد الاخصاب ،و8أسابيع بعد أخر دورة للأمتظهر الصورة جنين داخل الرحم عمره 6 أسابيع بعد الاخصاب ،و8أسابيع بعد أخر دورة للأم معلومات عامة الاختصاص طب التوليد and طب النساء الإدارة حالات مشابهة إجهاض،  وولادة جنين ميت&#...

 

 

Manasir

For the Emirati tribe, see Manasir (tribe). This article includes a list of references, related reading, or external links, but its sources remain unclear because it lacks inline citations. Please help improve this article by introducing more precise citations. (April 2016) (Learn how and when to remove this message) ManasirA Family from the Manasir tribeEthnicitySudanese ArabsLocationDar al-Manasir and Bayuda DesertPopulation80,000[1]LanguageSudanese ArabicReligionSunni Islam The Man...

 

 

Tao Geoghegan Hart

Tao Geoghegan HartTao Geoghegan Hart al Tour of Britain 2016Nazionalità Gran Bretagna Altezza183 cm Peso65 kg Ciclismo SpecialitàStrada Squadra Lidl-Trek CarrieraSquadre di club 2014Bissell Development Team2015-2016 Axeon2017-2019 Sky2019-2023 Ineos2024- Lidl-Trek Statistiche aggiornate al 1º gennaio 2024 Modifica dati su Wikidata · Manuale Tao Geoghegan Hart, [ˈteɪoʊ ˌgeɪgən ˈhɑːrt] ascoltaⓘ (Londra, 30 marzo 1995), è un ciclista su stra...

Frigidarium

The cold room of Roman baths This section needs additional citations for verification. Please help improve this article by adding citations to reliable sources in this section. Unsourced material may be challenged and removed. (July 2022) (Learn how and when to remove this message) The circular frigidarium, Roman Baths (Bath), England A frigidarium is one of the three main bath chambers of a Roman bath or thermae, namely the cold room.[1] It often contains a swimming pool.[1&#...

 

 

1986 Grand Prix motorcycle racing season

Sports season 1986 F.I.M. Grand Prix motorcycle racing season Previous 1985 Next 1987 1986 World Champions500cc – Eddie Lawson (Yamaha)250cc – Carlos Lavado (Yamaha)125cc – Luca Cadalora (Garelli)80cc – Jorge Martínez (Derbi) The 1986 Grand Prix motorcycle racing season was the 38th F.I.M. Road Racing World Championship season. This would be the last season where the premier class was held only in Europe until 2020. Season summary A second world championship for the consistent Eddie ...