Jim Busby was signed by the White Sox in 1948 and made his major league debut early during the 1950 season. He became the regular center fielder for the White Sox in 1951. A fast runner and a good contact hitter, Busby compiled his best offensive seasons early in his career, exceeding the .280 batting mark in 1951, 1953 (when he hit a career-best .312) and 1954. He also drove in 80 or more RBI during both 1953—54. But he earned a reputation as a superb defensive outfielder who committed only 42 errors in 3,394 total chances (.988) over his lengthy career. He was an American LeagueAll-Star in 1951.
When his career ended, in the middle of the 1962 season, he became a full-time coach with Houston (through 1967), then spent eight seasons (1968–75) on the staff of the Atlanta Braves, before returning to the American League to finish his coaching career with the White Sox (1976) and Seattle Mariners (1977–78).
As a player and coach, Busby had a 29-year MLB career.