Spencer starred as Billy Kennedy in the Australian soap opera Neighbours from 1994 to 2000. He later reprised his role in 2005, in an episode celebrating the show's 20th anniversary. His character was the son of long-term iconic Ramsay Street residents Dr. Karl Kennedy and Susan Kennedy.[5]
Spencer starred as intensive care specialist and surgeon Dr. Robert Chase on the Fox medical drama House from 2004 to 2012. He played Chase for the show's entire run, becoming the second longest-serving member of the title character's team.
Spencer began his musical career with the Australian Boys Choir, performing with them from 1986 to 1992.[10] He plays the violin in Band from TV, a group that includes his former House co-star Hugh Laurie. They play at various events, giving the money they earn to charity. The band played on Idol Gives Back in April 2008.[11][12]
He began dating neuroscientist Dr. Kali Woodruff Carr in 2014, and they were engaged in 2019. They were married on 27 June 2020.[15]
Spencer became a U.S. citizen in November 2021.[1]
Recognition
For Neighbours, Spencer was nominated for "Most Popular Actor" at the 1998 and 1999 Logie Awards. For House, he was nominated for "Choice TV Breakout Performance – Male" at the 2005 Teen Choice Awards and "Outstanding Performance by an Ensemble in a Drama Series" at the 2008 Screen Actors Guild Awards; he received a "Golden Boomerang" at the 2006 Australians in Film Breakthrough Awards for his work.[16] In 2007, he was included in People Magazine's100 Most Beautiful People issue. For Chicago Fire, he was again nominated at the 2013 Teen Choice Awards for "Choice TV Actor – Action".