In March 2009, Freeman signed with the Saskatchewan Roughriders of the CFL.[9] In the 2009 CFL season, Freeman was used primarily as a special teams tackler, recording a team high 25 special teams tackles. He was nominated as the team's Most Outstanding Rookie. In his second season with the Riders, Freeman saw more time as a regular linebacker. He made the starting lineup for one game in the regular season and started in two playoff games and the Grey Cup.[10] Jerrell Freeman won CFL Defensive Player of the Week honors in week 7 after recording three sacks against the BC Lions.[11] He led the team in sacks by the end of the season with seven.
The 2011 season was a breakout year for Freeman. Freeman lead the CFL in tackles with 106.[12] Freeman won CFL Defensive Player of the Week in week 10 and earned CFL Defensive Player of the Month for the month of September.[13]
Indianapolis Colts
In January 2012, Freeman signed with the Indianapolis Colts of the NFL.[14] In Week 1 against the Chicago Bears, Freeman returned a Jay Cutler interception for a touchdown in the first quarter.[15] Freeman had an outstanding first season with the Colts finishing with 145 tackles (90 solo and 55 assisted) and two sacks.[16] His 145 tackles was the fifth highest total in the league.[17] Freeman won the AFC Defensive Player of the Week award for his performance in a 23–7 win over the Kansas City Chiefs on December 22, 2013. He finished the game with seven tackles, one quarterback sack, one forced fumble, one interception, and three passes defended.[18] He was also initially credited with two interceptions, but one was later adjusted to a strip/sack for teammate Robert Mathis and a fumble recovery for Freeman.[19] In the 2013 season, he had 5.5 sacks, 126 total tackles, two interceptions, six passes defended, six forced fumbles, and two fumble recoveries.[20] In 2014, he recorded 95 combined tackles, six pass deflections, and one forced fumble in 12 games played.[21] On March 5, 2015, the Colts made a qualifying offer to Freeman,[22] which he signed on April 27.[23] In Week 17 of the 2015 season, Freeman had a 23-yard interception return for a touchdown in the 30–24 victory over the Tennessee Titans.[24] In the 2015 season, he finished with three sacks, 112 total tackles, one interception, two passes defended, and one fumble recovery in 13 games and starts.[25]
Chicago Bears
On March 12, 2016, Freeman signed a three-year, $12 million contract with the Chicago Bears.[26] He was suspended four games on November 21, 2016, for violating the league's performance-enhancing drug policy.[27] In the 2016 season, he appeared in 12 games and finished with 110 total tackles (86 solo) and five passes defended.[28]
On September 12, 2017, Freeman was placed on injured reserve after sustaining a pectoral injury and a concussion in Week 1 against the Atlanta Falcons.[29]
On October 30, the Chicago Bears announced that Freeman had been suspended for 10 games for violating the NFL's performance-enhancing drug policy for a second time.[30] Freeman apologized for the suspension, adding that his playing career might be in jeopardy due to a head injury and memory loss.[30]
On May 2, 2018, Freeman announced his retirement from the NFL.[31] He was suspended an additional two years by the NFL on May 11, 2018, after failing a third drug test.[32]