On May 3, 2019, President Donald Trump announced his intent to nominate Wilson to serve as a United States district judge for the United States District Court for the Middle District of Pennsylvania. On May 13, 2019, her nomination was sent to the Senate. President Trump nominated Wilson to the seat vacated by Judge Yvette Kane, who assumed senior status on October 11, 2018.[2] On June 5, 2019, a hearing on her nomination was held before the Senate Judiciary Committee.[3] On June 27, 2019, her nomination was reported out of committee by an 18–4 vote.[4] On November 6, 2019, the United States Senate invoked cloture on her nomination by an 89–3 vote.[5] On November 7, 2019, her nomination was confirmed by a 88–3 vote.[6] She received her judicial commission on November 8, 2019.[7]