Guillou made his debut for the France national team in March 1974 in a match against Romania, which France won 1–0. Between 1974 and 1978 he played 19 times for the French national side, including at the 1978 World Cup in Argentina.
Guillou gave former Arsenal manager Arsène Wenger his first break in coaching by appointing him as his assistant at AS Cannes in 1983.
Guillou was the founder of the Abidjan football school Académie de Sol Beni, eventually becoming the manager, technical director and coach at ASEC Abidjan. He currently runs a number of football schools in Africa and Thailand under the name Académie Jean-Marc Guillou (Academy J.M.G.) seeking to develop young footballers who are often transferred to European clubs,[3] the football talent academies are based in Abidjan, Antsika, Algiers and Bangkok.[4]