Grierson was drafted by Melbourne with their eighteenth selection and 135th overall in the 2016 AFL Women's draft.[1] She made her debut in the fifteen point loss to Brisbane at Casey Fields in the opening round of the 2017 season.[2] After the six point win against Carlton at Casey Fields in round four—in which she recorded sixteen disposals, five marks and two tackles—she was the round nominee for the AFLW Rising Star.[3] She played every match in her debut season to finish with seven games.[4]
Melbourne signed Grierson for the 2018 season during the trade period in May 2017.[5]