Jenkins attended D. W. Daniel High School in Central, South Carolina. He was named as an All-American by PrepStar as a senior where he had 79 tackles and four blocked kicks. He was named the South Carolina Coaches Association Upperstate AAA Lineman-of-the-Year, Daily Journal/Messenger Player-of-the-Year and was an AP All-State.
Jenkins was also a two-time All-region pick in basketball and was named All-region in the shot put (46-feet, 6-inches) and discus (111-feet, 10-inches).
Jenkins was rated as the 27th defensive tackle in the nation, and number one player in the state of South Carolina by Rivals.com. He was a member of the Rivals 250.
Jenkins was selected ninth in the second round, 41st overall, by the Washington Redskins in the 2011 NFL draft.[4] The Redskins signed Jenkins to a four-year, $4.783 million contract with a $1.978 million signing bonus on July 29, 2011.[5][6] Jenkins missed the entire 2011 season after tearing his ACL in a preseason game against the Baltimore Ravens, spending his entire rookie season on injured reserve.[7]
On July 28, 2013, it was announced that Jenkins would be suspended for the first four games of the 2013 season due to violating the league's substance policy.[10]
In Week 11, he recorded his first half a sack against the Philadelphia Eagles.[11] The following week, he recorded a full sack on quarterback Colin Kaepernick of the San Francisco 49ers.[12]
Chicago Bears
On March 24, 2015, Jenkins signed a one-year deal with the Chicago Bears.[13] In fifteen starts, Jenkins recorded a career-best 32 tackles, four sacks and six tackles-for-loss.[14]
New York Jets
On March 16, 2016, Jenkins signed a two-year, $7 million deal with the New York Jets.[15] He was released by the Jets on November 9, 2016.[16]