On July 21, 2021, President Joe Biden announced his intent to nominate Harpootlian to be the next United States ambassador to Slovenia.[3] On August 4, 2021, her nomination was sent to the Senate.[4] Hearings on her nomination were held before the Senate Foreign Relations Committee on November 2, 2021. On December 15, 2021, her nomination was reported out of committee.[5] On December 18, 2021, her nomination was confirmed in the Senate by voice vote.[6] She was appointed the 10th U.S. Ambassador to the Republic of Slovenia on December 20, 2021, and was sworn in on December 30, 2021. She presented her credentials to President of SloveniaBorut Pahor on February 17, 2022.[7]
Harpootlian resigned as U.S. Ambassador to Slovenia on July 31, 2024 and returned to the U.S. [8]