JWH-047

JWH-047
Legal status
Legal status
Identifiers
  • (1-Butyl-2-methyl-1H-indol-3-yl)(7-methyl-1-naphthalenyl)methanone
CAS Number
ChemSpider
UNII
Chemical and physical data
FormulaC25H25NO
Molar mass355.481 g·mol−1
3D model (JSmol)
  • CCCCn1c(c(c2c1cccc2)C(=O)c3cccc4c3cc(cc4)C)C
  • InChI=1S/C25H25NO/c1-4-5-15-26-18(3)24(21-10-6-7-12-23(21)26)25(27)20-11-8-9-19-14-13-17(2)16-22(19)20/h6-14,16H,4-5,15H2,1-3H3
  • Key:RQWLYQGWFKBOIY-UHFFFAOYSA-N

JWH-047 is a selective cannabinoid ligand that binds to both CB1 and CB2. It has a bindining affinity of Ki = 0.9 nM for the CB2 subtype, and more than 65 times selectivity over the CB1.[2]

In the United States, all CB1 receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-047 are Schedule I Controlled Substances.[3]

See also

References

  1. ^ "Stoffe gem. Anlagen zum BtMG". Retrieved 2024-11-23.
  2. ^ Aung MM, Griffin G, Huffman JW, Wu MJ, Keel C, Yang B, Showalter VM, Abood ME, Martin BR (2000). "Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding". Drug and Alcohol Dependence. 60 (2): 133–40. doi:10.1016/S0376-8716(99)00152-0. PMID 10940540.
  3. ^ 21 U.S.C. § 812: Schedules of controlled substances


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