Issa is at an elevation of 303 metres above sea level. Its neighbours include Samambaw to the north, Kojoperi to the east, Tabeasi to the south and Wogu to the west. The nearest airports are the Wa Airport and the Tamale Airport in the Northern Region.[2]
Gbele Game Reserve
Issa is located on the southern border of the Gbele Resource Centre and bird sanctuary. It is home to various endangered wildlife species as well as buffalo, hippopotamus, elephant, bushbuck and roan antelope.[3][4]