Isidore Battikha was ordained priest on April 11, 1980 and after that was named Chaplain of the Aleppinian Basilian. On August 25, 1992, he was appointed auxiliary bishop of the Melkite Patriarchate of Antioch and named titular bishop of Pelusium of Greek Melkites. On February 9, 2006, he was elected by the Synod of Bishops of the Melkite Greek Catholic Church as the successor of Abraham Nehmé as Archbishop of Homs. The Patriarch of Antioch Maximos V Hakim ordained him to the episcopate on August 25, 1992, and were his co-consecrators Néophytos Edelby, BA and François Abou Mokh, BS. Archbishop Battikha until his resignation was co-consekrator of the Archbishops Elias Chacour and Michel Abrass, BA.