IgSF CAMs (Immunoglobulin-like Cell Adhesion Molecules) are cell adhesion molecules that belong to Immunoglobulin superfamily.^[1] It is regarded as the most diverse superfamily of CAMs. This family is characterized by their extracellular domains containing Ig-like domains. The Ig domains are then followed by Fibronectin type III domain repeats and IgSFs are anchored to the membrane by a GPI moiety. This family is involved in both homophilic or heterophilic binding and has the ability to bind integrins or different IgSF CAMs.

Here is a list of some molecules of this family:

• NCAMs Neural Cell Adhesion Molecules
• ICAM-1 Intercellular Cell Adhesion Molecule
• VCAM-1 Vascular Cell Adhesion Molecule
• PECAM-1 Platelet-endothelial Cell Adhesion Molecule
• MAdCAM-1 Mucosal Vascular Addressin Cell Adhesion Molecule
• L1 family including L1 (protein), CHL1, Neurofascin and NrCAM
• SIGLEC family including Myelin-associated glycoprotein (MAG, SIGLEC-4), CD22 and CD83
• CTX family including CTX, Junctional adhesion molecule (JAM), BT-IgSF, Coxsackie virus and adenovirus receptor (CAR), VSIG, ESAM
• Nectins and related proteins, including CADM1 and other Synaptic Cell Adhesion Molecules
• CD2
• CD48
• HEPACAM
• HEPACAM2
• DSCAM - Down syndrome cell adhesion molecule