After completing her education, she taught for fourteen years.[3]
Wise joined the WCTU in 1891.[2] By 1900, she was a district president in the Iowa WTCU.[2] In 1913, she became president of the Iowa WCTU.[2] She served as president of the Iowa WCTU for 20 years In 1930 before becoming president of the national WCTU.[4]
President Herbert Hoover appointed her to the White House Conference on Child Health and Protection.[4] In 1940, Wise was appointed by President Franklin Roosevelt to the White House Conference on Children in a Democracy.[4]
Wise married twice. In 1889, she married James A. Wise.[3] The couple had one son who lived to adulthood. After the death of her first husband in 1892, Wise married Malcolm Smith in 1912.[3] She is known as both Ida B. Wise and Ida B. Wise Smith.
A member of the Disciples of Christ, Wise taught Sunday school from the age of 12.[2] In 1923, she was ordained as a minister, but she never served as a pastor to a congregation.[2]
Although Wise's primary cause was temperance, she also supported women's suffrage and child welfare work.[3] Beginning in 1933, she served as editor-in-chief of National WCTU's The Union Signal.[5] She was a semi-vegetarian.[1]