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Hypertensive crisis
Hypertensive crisis
Other names	Malignant hypertension, accelerated hypertension
Specialty	Cardiology
Symptoms	Headache, dizziness, malaise, shortness of breath, some cases asymptomatic
Complications	Hypertensive emergency
Treatment	Gradual reduction of blood pressure
Medication	Antihypertensives

Severely elevated blood pressure (equal to or greater than 180 mmHg systolic or 120 mmHg diastolic) is referred to as a hypertensive crisis (sometimes termed malignant or accelerated hypertension), due to the high risk of complications. People with blood pressures in this range may have no symptoms, but are more likely to report headaches (22% of cases)^[1] and dizziness than the general population.^[2] Other symptoms accompanying a hypertensive crisis may include visual deterioration due to retinopathy, breathlessness due to heart failure, or a general feeling of malaise due to kidney failure.^[3]

Most people with a hypertensive crisis are known to have elevated blood pressure, but additional triggers may have led to a sudden rise.^[4]

Symptoms & treatment

A "hypertensive emergency" is diagnosed when there is evidence of direct damage to one or more organs as a result of severely elevated blood pressure greater than 180 mmHg systolic or 120 mmHg diastolic.^[5] This may include hypertensive encephalopathy, caused by brain swelling and dysfunction, and characterized by headaches and an altered level of consciousness (confusion or drowsiness). Retinal papilledema and/or fundal bleeds and exudates are another sign of target organ damage. Chest pain may indicate heart muscle damage (which may progress to myocardial infarction) or sometimes aortic dissection, the tearing of the inner wall of the aorta. Breathlessness, cough, and the coughing up of blood-stained sputum are characteristic signs of pulmonary edema, the swelling of lung tissue due to left ventricular failure, an inability of the left ventricle of the heart to adequately pump blood from the lungs into the arterial system.^[4] Rapid deterioration of kidney function (acute kidney injury) and microangiopathic hemolytic anemia (destruction of blood cells) may also occur.^[4]

In these situations of hypertensive emergency, rapid reduction of the blood pressure is mandated to stop ongoing organ damage.^[4] In contrast there is no evidence that blood pressure needs to be lowered rapidly in hypertensive urgencies, where there is no evidence of target organ damage; over-aggressive reduction of blood pressure is not without risks.^[3] Use of oral medications to lower the BP gradually over 24 to 48h is advocated in hypertensive urgencies.^[4]

Etiologies

There are several etiologies of a hypertensive crisis, including a tumor. A rare, neuroendocrine tumor called a pheochromocytoma can cause a hypertensive crisis due to elevated levels of catecholamines.^[6]^[7]

References

^ Papadopoulos DP, Mourouzis I, Thomopoulos C, Makris T, Papademetriou V (December 2010). "Hypertension crisis". Blood Press. 19 (6): 328–36. doi:10.3109/08037051.2010.488052. PMID 20504242. S2CID 207471870.
^ Fisher ND, Williams GH (2005). "Hypertensive vascular disease". In Kasper DL, Braunwald E, Fauci AS, et al. (eds.). Harrison's Principles of Internal Medicine (16th ed.). New York, NY: McGraw-Hill. pp. 1463–81. ISBN 978-0-07-139140-5.
^ ^a ^b O'Brien, Eoin; Beevers, D. G.; Lip, Gregory Y. H. (2007). ABC of hypertension. London: BMJ Books. ISBN 978-1-4051-3061-5.
^ ^a ^b ^c ^d ^e Marik PE, Varon J (June 2007). "Hypertensive crises: challenges and management". Chest. 131 (6): 1949–62. doi:10.1378/chest.06-2490. PMID 17565029.
^ Chobanian, AV; Bakris, GL; Black, HR; Cushman, WC; Green, LA; Izzo JL, Jr; Jones, DW; Materson, BJ; Oparil, S; Wright JT, Jr; Roccella, EJ; National High Blood Pressure Education Program Coordinating Committee (Dec 2003). "Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure". Hypertension. 42 (6): 1206–52. doi:10.1161/01.hyp.0000107251.49515.c2. PMID 14656957.
^ Greenleaf, CE; Griffin, LA; Shake, JG; Orr, WS (July 2017). "Hypertensive crisis secondary to pheochromocytoma". Proceedings (Baylor University. Medical Center). 30 (3): 314–315. doi:10.1080/08998280.2017.11929629. PMC 5468026. PMID 28670069.
^ Bartikoski, SR; Reschke, DJ (3 March 2021). "Pheochromocytoma Crisis in the Emergency Department". Cureus. 13 (3): e13683. doi:10.7759/cureus.13683. PMC 8019065. PMID 33833909.