Holthusen is a German surname. Notable people with the surname include:

• Hans Egon Holthusen (1913–1997), German lyric poet, essayist, and literary scholar
• Henry Frank Holthusen (1894–1971), American lawyer and diplomat
• Mark Holthusen, American photographer

Surname list

This page lists people with the surname Holthusen.
If an internal link intending to refer to a specific person led you to this page, you may wish to change that link by adding the person's given name(s) to the link.