Rijgersma became a physician in 1858, and practiced medicine in the small town of Jisp and on the island of Marken. In 1861 he married Maria Henriette Gräfing; they had seven children.
When slavery was abolished in the Dutch colonies in 1863, he was one of six physicians appointed to provide medical care to the liberated slaves on the island of St. Martin in the Netherlands Antilles, where he served as government physician until his untimely death at the age of 42. There he collected many fossils, plants, birds, reptiles, fishes, mollusks, crustaceans and insects.
Hendrik van Rijgersma was an excellent painter and left to posterity many, mostly unpublished, drawings, sketches and water colors of plants, shells and other subjects.
^Beolens, Bo; Watkins, Michael; Grayson, Michael (2011). The Eponym Dictionary Reptiles. Baltimore: Johns Hopkins University Press. xiii + 296 pp. ISBN978-1-4214-0135-5. ("Rijgersma", p. 222).