This album marks the first time that Nick Oliveri and his previous bandmate, Josh Homme, have recorded music together since their well-publicized falling out in early 2004.
Homme appears on lead guitar on the final track, "The Last Train." Also appearing on that song is Homme and Oliveri's previous bandmate in Kyuss and Kyuss Lives!, John Garcia. The song was recorded before Homme and Scott Reeder filed suit against Garcia and Brant Bjork over the Kyuss band name.
In 2020, an early version of the album titled Shooters Bible was released by Oliveri's current label Heavy Psych Sounds Records. The album was originally recorded in 2010. It features some tracks with different titles and/or in a different order than Hell Comes to Your Heart; for example, "The Dirt Beneath" is titled "We Are Mondo Generator". It also includes the cover of Iggy Pop song "Dog Food".[4]