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H4C7
Identifiers
Aliases	H4C7, H4/l, H4FL, histone cluster 1, H4g, histone cluster 1 H4 family member g, H4 clustered histone 7, HIST1H4G
External IDs	OMIM: 602832; HomoloGene: 48222; GeneCards: H4C7; OMA:H4C7 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	26,246,996 bp
RNA expression pattern
	Top expressed in
	tibialis anterior muscle; ; optic nerve; ; deltoid muscle; ; cell; ; somatic cell; ; mononuclear cell; ; cerebral cortex; ; monocyte; ; rectum; ; small intestine;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; protein heterodimerization activity; DNA binding; histone binding; molecular function;
Cellular component	nucleosome; nucleus; chromosome;
Biological process	nucleosome assembly; biological process;
	Sources:Amigo / QuickGO
Orthologs
	8369
	n/a
	ENSG00000275663
	n/a
	Q99525
	n/a
	NM_003547
	n/a
	NP_003538
	n/a
	Wikidata
View/Edit Human

Histone H4-like protein type G is a protein that in humans is encoded by the HIST1H4G gene.^[3]^[4]^[5]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000275663 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.
^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
^ ^a ^b "Entrez Gene: HIST1H4G histone cluster 1, H4g".