HIST1H4A
Protein-coding gene in the species Homo sapiens
H4C1 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4H9O , 3WKJ , 3AYW , 3WA9 , 5B0Z , 5AVB , 2CV5 , 5AV5 , 3AV2 , 3WTP , 3AV1 , 3AZK , 3X1V , 5AV8 , 1F66 , 4QUU , 3CFS , 4YYK , 4QUT , 3NQJ , 3A6N , 3W99 , 5AVC , 2RS9 , 3F9Z , 3QZT , 3QBY , 3W97 , 4M38 , 4YM6 , 3CFV , 4HGA , 1EQZ , 2RJE , 3QZV , 1HQ3 , 4H9P , 3AZL , 3AFA , 1TZY , 3UVY , 5CPK , 3JPX , 4U9W , 4N3W , 4YYJ , 4YYD , 4H9N , 4H9R , 3AZI , 4LD9 , 3UVX , 3AZH , 5BNX , 4N4F , 1U35 , 4YYG , 3O36 , 2ARO , 5AV9 , 4H9S , 3AZF , 3W98 , 4GQB , 4H9Q , 5BNV , 3WAA , 3AZG , 3AZE , 2RNY , 1ZKK , 2QQS , 2LVM , 3X1T , 3AN2 , 2KWO , 3QZS , 3F9W , 5FFW , 5CPJ , 3F9X , 3IJ1 , 4YM5 , 3AZJ , 4YY6 , 3AZN , 2IG0 , 4YYH , 4YYI , 5CPI , 3W96 , 3R45 , 2KWN , 3F9Y , 5AV6 , 3AZM , 5BO0 , 3X1S , 4QYD , 4KGC , 3UVW , 4YYN , 3X1U , 3UW9 , 2F8N , 3NQU , 5B0Y , 4YYM , 5C3I , 4Z5T , 5B24 , 5FA5 , 4Z2M , 5E5A , 5FWE , 5B2I , 5B40 , 5B2J , 5JA4 , 5AY8 , 4ZUX
Identifiers Aliases H4C1 External IDs OMIM : 602822 ; MGI : 2448423 ; HomoloGene : 134481 ; GeneCards : H4C1 ; OMA :H4C1 - orthologs Wikidata
Histone H4 is a protein that in humans is encoded by the HIST1H4A gene .[ 5] [ 6] [ 7]
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[ 7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000278637 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061482 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics . 40 (2): 314– 22. doi :10.1006/geno.1996.4592 . PMID 9119399 . ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics . 80 (5): 487– 98. doi :10.1016/S0888-7543(02)96850-3 . PMID 12408966 . ^ a b "Entrez Gene: HIST1H4A histone cluster 1, H4a" .
Further reading
Pauli U, Chrysogelos S, Stein G, et al. (1987). "Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene". Science . 236 (4806): 1308– 11. Bibcode :1987Sci...236.1308P . doi :10.1126/science.3035717 . PMID 3035717 . Albig W, Doenecke D (1998). "The human histone gene cluster at the D6S105 locus". Hum. Genet . 101 (3): 284– 94. doi :10.1007/s004390050630 . PMID 9439656 . S2CID 38539096 . El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter" . Mol. Cell. Biol . 18 (5): 2535– 44. doi :10.1128/mcb.18.5.2535 . PMC 110633 PMID 9566873 . Lorain S, Quivy JP, Monier-Gavelle F, et al. (1998). "Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA" . Mol. Cell. Biol . 18 (9): 5546– 56. doi :10.1128/MCB.18.9.5546 . PMC 109139 PMID 9710638 . Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones" . Virology . 277 (2): 278– 95. doi :10.1006/viro.2000.0593 PMID 11080476 . Freire J, Covelo G, Sarandeses C, et al. (2001). "Identification of nuclear-import and cell-cycle regulatory proteins that bind to prothymosin alpha". Biochem. Cell Biol . 79 (2): 123– 31. doi :10.1139/bcb-79-2-123 . PMID 11310559 . Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA" . Virology . 289 (2): 312– 26. doi :10.1006/viro.2001.1129 PMID 11689053 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Yoon HG, Chan DW, Huang ZQ, et al. (2003). "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1" . EMBO J . 22 (6): 1336– 46. doi :10.1093/emboj/cdg120 . PMC 151047 PMID 12628926 . Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter" . EMBO J . 22 (24): 6550– 61. doi :10.1093/emboj/cdg631 . PMC 291826 PMID 14657027 . Phee H, Abraham RT, Weiss A (2005). "Dynamic recruitment of PAK1 to the immunological synapse is mediated by PIX independently of SLP-76 and Vav1". Nat. Immunol . 6 (6): 608– 17. doi :10.1038/ni1199 . PMID 15864311 . S2CID 23076354 .
External links
PDB gallery
1aoi : COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT
1eqz : X-RAY STRUCTURE OF THE NUCLEOSOME CORE PARTICLE AT 2.5 A RESOLUTION
1f66 : 2.6 A CRYSTAL STRUCTURE OF A NUCLEOSOME CORE PARTICLE CONTAINING THE VARIANT HISTONE H2A.Z
1hq3 : CRYSTAL STRUCTURE OF THE HISTONE-CORE-OCTAMER IN KCL/PHOSPHATE
1id3 : CRYSTAL STRUCTURE OF THE YEAST NUCLEOSOME CORE PARTICLE REVEALS FUNDAMENTAL DIFFERENCES IN INTER-NUCLEOSOME INTERACTIONS
1kx3 : X-Ray Structure of the Nucleosome Core Particle, NCP146, at 2.0 A Resolution
1kx4 : X-Ray Structure of the Nucleosome Core Particle, NCP146b, at 2.6 A Resolution
1kx5 : X-Ray Structure of the Nucleosome Core Particle, NCP147, at 1.9 A Resolution
1m18 : LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA
1m19 : LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA
1m1a : LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA
1p34 : Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
1p3a : Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
1p3b : Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
1p3f : Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
1p3g : Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
1p3i : Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
1p3k : Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
1p3l : Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
1p3m : Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
1p3o : Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
1p3p : Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants
1s32 : Molecular Recognition of the Nucleosomal 'Supergroove'
1tzy : Crystal Structure of the Core-Histone Octamer to 1.90 Angstrom Resolution
1u35 : Crystal structure of the nucleosome core particle containing the histone domain of macroH2A
1zbb : Structure of the 4_601_167 Tetranucleosome
1zla : X-ray Structure of a Kaposi's sarcoma herpesvirus LANA peptide bound to the nucleosomal core
2aro : Crystal Structure Of The Native Histone Octamer To 2.1 Angstrom Resolution, Crystalised In The Presence Of S-Nitrosoglutathione
2cv5 : Crystal structure of human nucleosome core particle
2f8n : 2.9 Angstrom X-ray structure of hybrid macroH2A nucleosomes
2fj7 : Crystal structure of Nucleosome Core Particle Containing a Poly (dA.dT) Sequence Element
2hio : HISTONE OCTAMER (CHICKEN), CHROMOSOMAL PROTEIN
2hue : Structure of the H3-H4 chaperone Asf1 bound to histones H3 and H4
2io5 : Crystal structure of the CIA- histone H3-H4 complex
2nzd : Nucleosome core particle containing 145 bp of DNA
