H. Houston Merritt

Hiram Houston Merritt Jr.
Born(1902-01-12)January 12, 1902
Wilmington, North Carolina
DiedJanuary 9, 1979(1979-01-09) (aged 76)
Boston, Massachusetts
OccupationAcademic neurologist
Known forDiscovery of the anticonvulsant properties of phenytoin

Hiram Houston Merritt Jr. (January 12, 1902, Wilmington, North Carolina – January 9, 1979, Boston, Massachusetts) was a renowned academic neurologist. Serving as chair of the Neurological Institute of New York and Neurologist-in-Chief at NewYork-Presbyterian Hospital/Columbia University Medical Center in Manhattan's Washington Heights from 1948 to 1967,[1] Merritt played a pivotal role in the training of numerous neurologists, with 35 of his students ascending to department chair positions in universities across the US. He also held the deanship of the Columbia University College of Physicians and Surgeons from 1958 to 1970.[2]

Merritt's influential contributions to neurology included the discovery of the anticonvulsant properties of phenytoin (Dilantin) in 1938, alongside Tracy Putnam. This discovery marked a significant breakthrough in seizure management, as phenytoin effectively controlled seizures without the sedative effects associated with phenobarbital.

According to Goodman and Gilman's Pharmacological Basis of Therapeutics:

In contrast to the earlier accidental discovery of the antiseizure properties of potassium bromide and phenobarbital, phenytoin was the product of a search among nonsedative structural relatives of phenobarbital for agents capable of suppressing electroshock convulsions in laboratory animals.[3]

He also was the sole author of the first five editions of Merritt's Neurology; this popular textbook is in its fourteenth edition (Louis, Mayer and Noble, 2021). His early work on the normal properties of the cerebrospinal fluid (CSF) was updated and published by one of his students, Robert Fishman, in a text that is the acknowledged standard on the topic.

Merritt was also known in his day as an expert on neurosyphilis; his 1946 monograph on the topic provided an overview of this condition, which almost disappeared from the medical eye shortly thereafter owing to the advent of penicillin.

Charles Poser, another eminent neurologist, worked under Merritt, and credited him teaching him the importance of a thorough diagnosis.[4]

Biography

He was a son of Hiram Houston Merritt Sr. (January 6, 1870 - May 9, 1945) and Dessie Ella Cline (September 23, 1872 - January 7, 1946), who were married on January 24, 1898, in Morehead Township, Guilford County, North Carolina.[citation needed]

In 1968, he was sent by the Department of Health to Portugal to assist local doctors after Salazar had a brain haemorrhage.

Merritt died in 1979 from complications of cerebrovascular disease and normal pressure hydrocephalus; ironically, the latter condition was a syndrome whose existence he had never fully accepted during his career. His students who were treating him in New York disagreed over the proper course of action. Eventually, he was taken to the Massachusetts General Hospital, where he died from the after-effects of a neurosurgical operation.[citation needed]

References

  1. ^ Rowland, L. P. (1979-03-01). "H. Houston Merritt 1902–1979". Neurology. 29 (3): 277–279. doi:10.1212/WNL.29.3.277. ISSN 0028-3878. PMID 377132.
  2. ^ "A revisionist history of American neurology"
  3. ^ Goodman and Gilman's Pharmacological Basis of Therapeutics (10th ed.). New York: McGraw-Hill. 2001.
  4. ^ Dave Lounsbury. "Honouring Dr. Charles M. Poser FRCPE". Royal Society. Archived from the original on 2016-03-19. Retrieved 2016-03-15. Charles once said that the parts of neurology most attractive to him were learned from his two mentors: "Merritt, who taught me to make a diagnosis on the basis of a good history, and van Bogaert, who helped me understand the underlying pathology."

Read other articles:

Douglas Stone

Artikel ini sebatang kara, artinya tidak ada artikel lain yang memiliki pranala balik ke halaman ini.Bantulah menambah pranala ke artikel ini dari artikel yang berhubungan atau coba peralatan pencari pranala.Tag ini diberikan pada November 2022. A. Douglas Stone, MA, Ph.D (lahir 1 Januari 1958) adalah seorang Profesor Fisika dan Fisika Terapan Carl Morse di Yale University[1] yang menemukan antilaser.[2] Temuannya ini berangkat dari fenomena bahwa laser akan merusak daya tahan...

 

 

Budi Susilo

Budi Susilo Atase Pertahanan Udara RI Moskow, Russia Informasi pribadiLahirBlitar, Jawa TimurKebangsaanIndonesiaAlma materAkademi Angkatan Udara (1998)Penghargaan sipil1. Juara Pidato Bahasa Inggris[1]2. 1000 Jam Terbang[2]Karier militerPihak IndonesiaDinas/cabang TNI Angkatan UdaraMasa dinas1998 - SekarangPangkat KolonelSatuanKorps Penerbang (Tempur)Sunting kotak info • L • B Kolonel Pnb. Budi ”Grizzly” Susilo, S.T., M.Han., lahir di Blitar, Jawa T...

 

 

Madu Murni

Madu MurniPoster resmiSutradaraMonty TiwaProduser Chand Parwez Servia Fiaz Servia SkenarioMusfar YasinPemeran Irish Bella Ammar Zoni Aulia Sarah Penata musikAndi RiantoSinematograferJimmy FajarPenyuntingCesa David LuckmansyahPerusahaanproduksiStarvisionTanggal rilis 30 Juni 2022 (2022-06-30) Durasi96 menitNegaraIndonesiaBahasaIndonesiaPendapatankotorRp 2,4 miliar Madu Murni adalah film drama komedi Indonesia tahun 2022 yang disutradarai oleh Monty Tiwa. Film produksi Starvision Plu...

The Prism (Dubai)

Artikel ini membahas mengenai bangunan, struktur, infrastruktur, atau kawasan terencana yang sedang dibangun atau akan segera selesai. Informasi di halaman ini bisa berubah setiap saat (tidak jarang perubahan yang besar) seiring dengan penyelesaiannya. The PrismInformasi umumLokasiDubai, Uni Emirat ArabPerkiraan rampung2008Data teknisJumlah lantai36Desain dan konstruksiArsitekDewan Architects & EngineersPengembangDubai Properties The Prism merupakan sebuah menara bertingkat 36 di Business...

 

 

George Akerlof

George AkerlofLahirGeorge Arthur Akerlof17 Juni 1940 (umur 83)New Haven, ConnecticutKebangsaanUnited StatesInstitusiUniversity of California, BerkeleyMazhabNew Keynesian economicsAlma materMIT (Ph.D.)Yale University (B.A.)DipengaruhiRobert SolowKontribusiInformation asymmetryEfficiency wagesPenghargaanNobel Prize in Economics (2001)Informasi di IDEAS / RePEc George Arthur Akerlof (lahir 17 Juni 1940 di New Haven, Connecticut) ialah ekonom Amerika Serikat. Akerlof menerima...

 

 

Zlatibor Lončar

Serbian doctor and politician Zlatibor LončarЗлатибор ЛончарLončar in 2021Minister of HealthIn office27 April 2014 – 26 October 2022Prime MinisterAleksandar VučićIvica Dačić (acting)Ana BrnabićPreceded bySlavica Đukić DejanovićSucceeded byDanica Grujičić Personal detailsBorn (1971-08-03) 3 August 1971 (age 52)Belgrade, SR Serbia, SFR YugoslaviaPolitical partySNSSpouseVesna LončarChildren1Alma materUniversity of BelgradeOccupationDoctorpolitician Zlat...

Ranca Upas

Ranca UpasJenisBumi PerkemahanLokasiCiwidey, Bandung, Jawa Barat, IndonesiaDioperasikan olehPerhutani Ranca Upas atau Kampung Cai Ranca Upas adalah salah satu bumi perkemahan di Bandung, Jawa Barat, Indonesia. Terletak di Jalan Raya Ciwidey Patenggang KM. 11, Alam Endah, Ciwidey Kabupaten Bandung, dengan jarak sekitar 50 km dari pusat Kota Bandung. Memiliki luas area sekitar 215 Hektar, berada pada 1700 meter di atas permukaan laut, dengan suhu udara sekitar 17 °C - 20 °...

 

 

Человек прямоходящий

† Человек прямоходящий Научная классификация Домен:ЭукариотыЦарство:ЖивотныеПодцарство:ЭуметазоиБез ранга:Двусторонне-симметричныеБез ранга:ВторичноротыеТип:ХордовыеПодтип:ПозвоночныеИнфратип:ЧелюстноротыеНадкласс:ЧетвероногиеКлада:АмниотыКлада:Синапсиды�...

 

 

Liga 2 (Indonesia) 2017

Liga 2Musim2017JuaraPersebaya SurabayaPromosi Persebaya Surabaya (juara) PSMS Medan (kedua) PSIS Semarang (ketiga) Degradasi757 Kepri Jaya FC, PSBL Langsa, Persih Tembilahan, Pro Duta FC(DQ), Persikad Depok, PS Bengkulu, PS Lampung Sakti, Persikabo Bogor, Persibas Banyumas, Persip Pekalongan, Persijap Jepara,Persibangga Purbalingga, Sragen United, PPSM Magelang, Persipon Pontianak, Persiba Bantul, Persatu Tuban, Persinga Ngawi, Madiun Putra FC, PSBI Blitar, PSBK Blitar Kota, Perssu Sumenep, P...

Albanian Lictor Youth

Youth wing of the Albanian Fascist Party Albanian Lictor YouthDjelmnia e Liktorit ShqiptarLeaderGiovanni GiroFounded2 June 1939HeadquartersTirana, AlbaniaIdeologyFascismMother partyAlbanian Fascist Party Albanian Lictor Youth (Albanian: Djelmnia e Liktorit Shqiptar, Italian: Gioventù del Littorio Albanese, abbreviated G.L.A.) was a youth organization which served as the youth wing of the Albanian Fascist Party.[1] The Albanian Lictor Youth was one of the associated organizations of t...

 

 

Richard Linklater

Richard Linklater nel 2015 Richard Stuart Linklater (Houston, 30 luglio 1960) è un regista, sceneggiatore e produttore cinematografico statunitense. Annoverato tra i migliori registi del nuovo cinema statunitense, è noto per aver diretto la trilogia di film Prima dell'alba (1995), Before Sunset - Prima del tramonto (2004) e Before Midnight (2013), per i quali ha ottenuto due candidature ai Premi Oscar. Nel 2014 il suo film Boyhood, girato nell'arco di 12 anni, ha ottenuto il plauso della cr...

 

 

Dubat

Armed Irregular Bands employed in Italian Somaliland Dubat from Italian Somalia with rifle, futa and lanyard, 1938 Dubat (Wadaad's Somali :,دُوب عد); Arabic:العمائم البيضاء ); ḍubbāṭ: English: White turban) was the designation given to members of the semi-regular armed bands employed by the Italian Royal Corps of Colonial Troops (Regio Corpo di Truppe Coloniali in Italian) in Italian Somaliland from 1924 to 1941. The word dubat was derived from a Somali phrase me...

Sam Collins (footballer, born 1977)

English football manager (born 1977) Sam Collins Collins as manager of York City in 2018Personal informationFull name Sam Jason Collins[1]Date of birth (1977-06-05) 5 June 1977 (age 46)[2]Place of birth Pontefract, EnglandHeight 6 ft 3 in (1.91 m)[3]Position(s) Centre backYouth career000–1994 Huddersfield TownSenior career*Years Team Apps (Gls)1994–1999 Huddersfield Town 37 (0)1999–2002 Bury 82 (2)2002–2006 Port Vale 135 (11)2005–2006 → ...

 

 

Grenelle de l'environnement

Pour les articles homonymes, voir Grenelle. Le logo du Grenelle de l'environnement. Le Grenelle Environnement (souvent appelé Grenelle de l'environnement) est un ensemble de rencontres politiques organisées en France en septembre et décembre 2007, visant à prendre des décisions à long terme en matière d'environnement et de développement durable, en particulier pour restaurer la biodiversité par la mise en place d'une trame verte et bleue et de schémas régionaux de cohérence écol...

 

 

VLEGA Gaucho

This article includes a list of general references, but it lacks sufficient corresponding inline citations. Please help to improve this article by introducing more precise citations. (April 2010) (Learn how and when to remove this message) Wheeled all-terrain vehicle VLEGA Gaucho Armored version of the Gaucho, exhibited in 2007TypeWheeled all-terrain vehiclePlace of originArgentina, BrazilService historyIn service–SpecificationsCrew4-6Mainarmamentdepends on the versionEngineM...

Kaleido Star

Japanese anime television series Kaleido StarVolume 1 DVD cover (US release)カレイドスター(Kareido Sutā)GenreDrama,[1] sports[2]Created byJunichi Sato Anime television seriesDirected byJunichi Sato (1–26)Yoshimasa Hiraike (27–51)Produced byYoshiyuki FuruyaTakeshi SasamuraShunji NamikiWritten byReiko YoshidaMusic byMina KubotaStudioGonzoG&G EntertainmentLicensed byNA: ADV Films (expired)Crunchyroll[3]Original networkTV Tokyo...

 

 

أنبياء الكتاب المقدس

يفتقر محتوى هذه المقالة إلى الاستشهاد بمصادر. فضلاً، ساهم في تطوير هذه المقالة من خلال إضافة مصادر موثوق بها. أي معلومات غير موثقة يمكن التشكيك بها وإزالتها. (مارس 2020) يجب على المرء أن يميز مفاهيمياً بين الأنبياء بمعنى الكتب النبوية والأفراد الذين يطلق عليهم الأنبياء. تتضمن...

 

 

Rikichi Andō

Rikichi AndōJenderal Jepang Andō Rikichi pada tahun 1940Lahir3 April 1884Prefektur Miyagi, JepangMeninggal19 April 1946(1946-04-19) (umur 62)Shanghai, ChinaPengabdianKekaisaran JepangDinas/cabang Tentara Kekaisaran JepangLama dinas1914 - 1945PangkatJenderalKomandanTentara Dua Puluh SatuTentara Wilayah China SelatanTentara Taiwan JepangTentara Wilayah KesepuluhPerang/pertempuranPerang China-Jepang DuniaPekerjaan lainGubernur-Jenderal Taiwan Ini adalah nama Jepang, nama keluarg...

Jeff Goldblum

American actor and musician (born 1952) Jeff GoldblumGoldblum in 2019BornJeffrey Lynn Goldblum (1952-10-22) October 22, 1952 (age 71)West Homestead, Pennsylvania, U.S.OccupationsActormusicianYears active1974–presentSpouses Patricia Gaul ​ ​(m. 1980; div. 1985)​ Geena Davis ​ ​(m. 1987; div. 1991)​ Emilie Livingston ​(m. 2014)​Children2Musical careerGenresJaz...

 

 

Oligochaeta

«Lombriz» redirige aquí. Para otras acepciones, véase Lombriz (desambiguación).   Lombrices Lombriz de tierra (Lumbricus terrestris)TaxonomíaReino: AnimaliaFilo: AnnelidaClase: ClitellataSubclase: Oligochaeta (P)Grube, 1850Órdenes y subórdenes Lombrices acuáticas: Capilloventrida Enchytraeida Haplotaxida Haplotaxina Tubificina Lumbriculida Moniligastrida Lombrices de tierra: Crassiclitellata Lumbricina Megascolecida [editar datos en Wikidata] Los oligoquetos (Oligochae...