Rondón was selected by the Chicago Cubs from the Indians in the 2012 Rule 5 Draft.[2] He made the Cubs' 2013 Opening Day roster and made his major league debut on April 3. In his first season with the Cubs, he had a 2–1 record with a 4.77 ERA with 44 SO.
After struggles by Cubs closer José Veras early in the 2014 season, Rondón was named the new Cubs closer. He had a breakout 2014 season. He earned two saves in the 2015 National League Division Series against the St. Louis Cardinals, including a save in the series-clinching game 4.[3] With the addition of Aroldis Chapman in late July 2016, Rondon was moved to the setup role in the bullpen. Rondon finished 2016 with a 2–3 record and a 3.53 ERA in 54 appearances. The Cubs won the 2016 World Series over the Cleveland Indians, ending the Cubs' 108-year drought.[4] He was non-tendered and became a free agent on December 1, 2017.
Houston Astros
On December 15, 2017, Rondón signed a two-year contract with the Houston Astros.[5] In 2018, he was 2–5 with 15 saves and a 3.20 ERA, pitching 59 innings in 63 relief appearances.[6] In 2019, Rondón was 3–2 with a 3.71 ERA, appearing in 62 games (one start) and pitching 60+2⁄3 innings.[6] He became a free agent following the 2019 season.
Arizona Diamondbacks
On January 9, 2020, Rondón and the Arizona Diamondbacks agreed to a $3 million, one-year contract.[7] During the shortened 2020 season, he made 23 relief appearances with the Diamondbacks, compiling a 7.65 ERA while striking out 23 batters in 20 innings; he recorded one win and no losses.[6] He became a free agent following the season.
Philadelphia Phillies
On February 2, 2021, Rondón signed a minor league contract with the Philadelphia Phillies organization and was invited to spring training.[8] On March 25, 2021, Rondón requested and was granted his release by the Phillies.[9]
Boston Red Sox
On April 3, 2021, Rondón signed a minor league contract with the Boston Red Sox organization.[10] On April 9, 2021, Rondón retired from professional baseball.[11]
