Brisebois was selected by the Acadie–Bathurst Titan in the first round (5th overall) in the 2013 Quebec Major Junior Hockey League (QMJHL) draft.[1] Though the team placed last in 2015, he earned praise for his defensive play.[2] After playing for three years, he requested a trade and was subsequently dealt during the 2016 QMJHL draft to the Charlottetown Islanders, along with defenceman Jake Barter, in exchange for Luc Deschenes, a second-round pick in 2017 and a first-round pick in 2018.[3][4]
Two months after arriving in Charlottetown, his teammates voted him captain.[5] Brisebois recorded his first goal as an Islander in his first game on October 2, 2016.[6]
On February 14, 2019, Brisebois made his NHL debut with the Canucks in a 4–3 shootout win against the Los Angeles Kings.[10]
On October 30, 2020, Brisebois re-signed with Vancouver to a one-year, $700,000 contract.[11] In March 2023, after appearing in nine games with the team, Brisebois signed a two-year extension with the Canucks.[12]