The Grisamore House is a historic home located in downtown Jeffersonville, Indiana. It was built by two brothers from Philadelphia, David and Wilson Grisamore, in 1837. It is a 2+1⁄2-story, Federal style brick double house with Greek Revival style design elements. The front facade features three stucco-coated, two-story Doric order columns in antis and two projecting second story balconies.[2] It has housed several important Jeffersonville families. For example, future president William Henry Harrison gave a speech on the front porch in 1840 while campaigning to become president.