He attended Stockdale High School in Bakersfield and was an all-area selection as a junior and senior. He was first-team selectee for the Southwest Yosemite League (SWYL). As a senior, he was co-Most Valuable Player of the SWYL.[1]
Desme began his professional baseball career with the Short-Season Vancouver Canadians of the Northwest League in 2007. Desme was selected in the second round of the 2007 Major League Baseball Draft before being assigned to the Canadians.[5] He batted .261 with three doubles, one home run, six RBIs and two stolen bases in 12 games. The next season, 2008, he only played two games after he injured his wrist in 2007 and his shoulder the next year.[6] In 2009, Desme had an extraordinary season. He hit a combined .288 with 31 doubles, six triples, 31 home runs, 89 RBIs and 40 stolen bases in 131 games with the Class-A Kane County Cougars and the Class-A Advanced Stockton Ports.
On January 22, 2010, it was reported that Desme planned to retire from professional baseball and study to become a priest. He said this about his situation:
I was doing well at baseball. But I really had to get down to the bottom of things - I love the game, but I aspire to higher things. I wasn't at peace where I was at. I have no regrets.