Gmina Radziłów is a rural gmina (administrative district) in Grajewo County, Podlaskie Voivodeship, in north-eastern Poland. Its seat is the village of Radziłów, which lies approximately 27 kilometres (17 mi) south of Grajewo and 61 km (38 mi) north-west of the regional capital Białystok.
The administrative district (Polish: gmina) covers an area of 199.38 square kilometres (77.0 sq mi), and as of 2006 its total population is 5,114 (5,024 in 2011).