McLendon's research is focused on inorganic and physical biochemistry. He has published over 200 peer reviewed papers and received national research awards, including the ACS Award in Pure Chemistry, the Eli Lilly Award in Biological Chemistry, Sloan Dreyfus Award, and Guggenheim Fellowships. His publications range from solar nanotechnology to cell death pathways. His most recent research has direct implications for the diagnosis and treatment of cancer and other diseases. He has been involved in launching several biotech startups, including Tetralogic Pharmaceuticals.[1]
As provost, McLendon outlined a broad strategy called "The Rice Initiatives." The initiatives encompass three main areas of focus: bioscience and health, energy and the environment, and international strategy. He is also pursuing an international strategy for expanding Rice's image abroad.[2]