The economy of General Pueyrredón Partido is dominated by the summer tourist season (December–February), when hundreds of thousands of vacationers make their way from the Gran Buenos Aires urban area to the Atlantic coast of Argentina. The other major industry is fishing. The main city of General Pueyrredón Partido, Mar del Plata, holds one of the most important fishing ports of Argentina.
Other industries include arable farming, beef and dairy farming, related agricultural industries, metallurgy and the service sector.