The trailhead for Garnet Canyon is found at Lupine Meadows, and the canyon itself is reached after several miles of hiking through forest and switchbacks which climb a large lateral moraine. The entrance to the canyon is guarded by a boulderfield that requires some Class 3 scrambling to cross. Beyond the boulderfield is the popular camping area known as the Meadows, above which the canyon divides into north and south forks. The north fork leads up to the lower saddle between Middle Teton and Grand Teton and is the starting point for many classic climbs on Grand Teton. The south fork climbs up to a saddle between Middle Teton and South Teton and is the starting point for some of the easier routes up those two summits.
Backcountry camping is allowed, by permit, in Garnet Canyon at areas designated by the National Park Service. Camping permits can be obtained in advance via registration or in person at the Jenny Lake Ranger Station.