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GNA15
Identifiers
Aliases	GNA15, GNA16, G protein subunit alpha 15, HG1L
External IDs	OMIM: 139314; MGI: 95770; HomoloGene: 1563; GeneCards: GNA15; OMA:GNA15 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	3,163,749 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	81,360,059 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; gingival epithelium; ; monocyte; ; oral cavity; ; skin of abdomen; ; buccal mucosa cell; ; amniotic fluid; ; skin of leg; ; olfactory zone of nasal mucosa; ; periodontal fiber;
	Top expressed in
	granulocyte; ; lip; ; esophagus; ; embryo; ; transitional epithelium of urinary bladder; ; embryo; ; morula; ; blastocyst; ; zone of skin; ; stroma of bone marrow;
	More reference expression data
	n/a
Gene ontology
Molecular function	guanyl nucleotide binding; nucleotide binding; GTP binding; metal ion binding; GTPase activity; G-protein beta/gamma-subunit complex binding; G protein-coupled receptor binding; signal transducer activity;
Cellular component	plasma membrane; heterotrimeric G-protein complex;
Biological process	platelet activation; phospholipase C-activating G protein-coupled receptor signaling pathway; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway; phospholipase C-activating dopamine receptor signaling pathway; activation of phospholipase C activity; signal transduction; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2769
	14676
	ENSG00000060558
	ENSMUSG00000034792
	P30679
	P30678
	NM_002068
	NM_010304
	NP_002059
	NP_034434
	Wikidata
View/Edit Human	View/Edit Mouse

Guanine nucleotide-binding protein subunit alpha-15 is a protein that in humans is encoded by the GNA15 gene.^[5]^[6]^[7] G₁₅α is a member of the Gq alpha subunit family, and functions as a constituent of a heterotrimeric G protein in cell signal transduction. It was also previously known as G₁₆α.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000060558 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034792 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Wilkie TM, Gilbert DJ, Olsen AS, Chen XN, Amatruda TT, Korenberg JR, Trask BJ, de Jong P, Reed RR, Simon MI, et al. (Jun 1993). "Evolution of the mammalian G protein alpha subunit multigene family". Nat Genet. 1 (2): 85–91. doi:10.1038/ng0592-85. PMID 1302014. S2CID 31888533.
^ "Entrez Gene: GNA15 G protein subunit alpha 15 [ Homo sapiens (human) ]". Retrieved 2019-07-25.
^ GUANINE NUCLEOTIDE-BINDING PROTEIN, ALPHA-15; GNA15 at OMIM. Retrieved JULY 25, 2019.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000060558 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034792 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1302014-5] Wilkie TM, Gilbert DJ, Olsen AS, Chen XN, Amatruda TT, Korenberg JR, Trask BJ, de Jong P, Reed RR, Simon MI, et al. (Jun 1993). "Evolution of the mammalian G protein alpha subunit multigene family". Nat Genet. 1 (2): 85–91. doi:10.1038/ng0592-85. PMID 1302014. S2CID 31888533.

[entrez-6] "Entrez Gene: GNA15 G protein subunit alpha 15 [ Homo sapiens (human) ]". Retrieved 2019-07-25.

[7] GUANINE NUCLEOTIDE-BINDING PROTEIN, ALPHA-15; GNA15 at OMIM. Retrieved JULY 25, 2019.

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GNA15

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