Applegate played Cogsworth in the national tour of Beauty and the Beast. He originated the roles of Inspector Kemp and The Blind Hermit in the Broadway musicalYoung Frankenstein (2007).[3] He originated the role of the Monsignor in the Broadway production of Sister Act (2011)[4] and the role of Father Jack O'Brien in The Last Ship, which premiered on Broadway in October 2014.[3]
Applegate appeared Off-Broadway at Lincoln Center's Mitzi Newhouse Theater in the musical Happiness in 2009, directed and choreographed by Susan Stroman.[7] Applegate played the role of "Panisse" in the Encores! staged concert of Fanny in February 2010.[8] He participated in a reading of a new musical, Presto Change-O in December 2014, directed by Marc Bruni, as a presentation of the Barrington Stage Company Musical Theatre Lab.[9] He appeared in the national tour of Anything Goes, as "Moonface Martin", which started in October 2012.[10]
Applegate has played the role of the Wizard in the Broadway production Wicked,[11][3] played the role of Constable Joe in the Broadway musical Tuck Everlasting,[12][3] and also played the role of Uncle Patrick Carney in the Broadway play The Ferryman.[13]
Applegate was a member of the resident acting company of the Guthrie Theatre for three years.[5]