James made an impression playing the character of Marcy Wade on One Life to Live from 1970 to 1972, and was afterward asked to join the cast of All My Children as Kitty Shea, a dancer searching for her birth mother. She initially departed that program around its expansion to a full hour to become a singer. She later met Agnes Nixon, the show's creator, and expressed an interest to rejoin the show. Her character Kitty had died, but Nixon created the character of Kelly Cole, an addicted nightclub performer who was also Kitty's long-lost twin sister. She was given a chance to sing and even composed the song "Colored Lights" when another character, Tad Martin, was suffering from addiction.[citation needed]
James was written off All My Children in 1980 and then pursued a career in directing. Her directing credits include All My Children and Loving. She then moved to Los Angeles as a producer, where she worked on General Hospital, Santa Barbara and Days of Our Lives. While she was producing General Hospital in 1994–1995, the show was twice awarded the Daytime Emmy as Outstanding Drama Series.[2][3] In 1995, James returned to New York and All My Children, which earned its second Outstanding Daytime Drama with her as producer.[4]
In 1998, James left the production team of All My Children, but stayed with ABC Daytime in a consulting position and as the head of its writer development program for the next year.[citation needed]