Flora was platted on April 7, 1897.[3] By 1910, it had a population of 200 residents and an eight-room school. It is considered "the most substantial town to fail" in the Northeast Oregon region.[3]
The community was named after the daughter of the first postmaster, A. D. Buzzard.[4] Flora post office operated from 1890–1966.[4] The Flora School, built in 1915, is on the National Register of Historic Places.[5] Now known as the Flora School Education Center, the schoolhouse has been restored as a pioneer arts education center.[6][7]