December 1784 – Lord Gower (Lord Stafford from 1786) succeeds Rutland as Lord Privy Seal (Rutland remains Viceroy of Ireland). Lord Camden succeeds Gower as Lord President.
November 1787 – Lord Buckingham succeeds Rutland as Lord Lieutenant of Ireland.
July 1788 – Lord Chatham, Pitt's elder brother, succeeds Lord Howe as First Lord of the Admiralty.
June 1789 – William Grenville (Lord Grenville from 1790) succeeds Lord Sydney as Home Secretary.
October 1789 – Lord Westmorland succeeds Buckingham as Lord Lieutenant of Ireland.
June 1791 –
Grenville succeeds the Duke of Leeds (Lord Carmarthen before 1789) as Foreign Secretary.
Henry Dundas succeeds Grenville as Home Secretary.
February 1795 – Lord Cornwallis succeeds the Duke of Richmond as Master-General of the Ordnance.
March 1795 – Camden succeeds Fitzwilliam as Lord Lieutenant of Ireland.
September 1796 – Chatham succeeds Mansfield as Lord President. Chatham remains Lord Privy Seal.
February 1798 – Westmorland succeeds Chatham as Lord Privy Seal. Chatham remains Lord President.
June 1798 – Cornwallis succeeds Camden as Lord Lieutenant of Ireland, remaining also Master-General of the Ordnance.
February 1801 – Grenville, Spencer, and Windham resign from the Cabinet. The first two are succeeded by Lord Hawkesbury and Lord St Vincent, while Windham's successor is not in the Cabinet.