Following his involvement in the Magione conspiracy against Cesare Borgia, Paolo Orsini was arrested and Fabio fled.[4] The following year, Fabio Orsini and Ludovico of Pitigliano returned with 400 horse and 500 foot soldiers to challenge Cesare,[5] but an alliance between the Borgia and the Colonna families allowed Cesare to prevail, and on 24 August Ludovico was defeated, forcing Fabio to flee once again.[6]