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FGD4
Identifiers
Aliases	FGD4, CMT4H, FRABP, ZFYVE6, FYVE, RhoGEF and PH domain containing 4
External IDs	OMIM: 611104; MGI: 2183747; HomoloGene: 26727; GeneCards: FGD4; OMA:FGD4 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	32,646,050 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	16,418,413 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; Achilles tendon; ; mucosa of ileum; ; retinal pigment epithelium; ; pancreatic epithelial cell; ; trabecular bone; ; visceral pleura; ; mucosa of paranasal sinus; ; lower lobe of lung; ; Skeletal muscle tissue of biceps brachii;
	Top expressed in
	epithelium of small intestine; ; retinal pigment epithelium; ; pineal gland; ; interventricular septum; ; granulocyte; ; Epithelium of choroid plexus; ; ciliary body; ; iris; ; epithelium of stomach; ; Rostral migratory stream;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; small GTPase binding; actin binding; guanyl-nucleotide exchange factor activity;
Cellular component	cytoplasm; cytosol; Golgi apparatus; cell projection; filopodium; ruffle; cytoskeleton; lamellipodium;
Biological process	regulation of GTPase activity; filopodium assembly; cytoskeleton organization; regulation of cell shape; positive regulation of apoptotic process; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; actin cytoskeleton organization; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	121512
	224014
	ENSG00000139132
	ENSMUSG00000022788
	Q96M96; Q49A55
	Q91ZT5
NM_001304480; NM_001304481; NM_001304483; NM_001304484; NM_139241;
	NM_001330373; NM_001330374; NM_001370297; NM_001370298; NM_001384126; NM_001384127; NM_001384128; NM_001384130; NM_001384131; NM_001384132; NM_001385118
	NM_001301817; NM_001301818; NM_139232; NM_139233; NM_139234
NP_001291409; NP_001291410; NP_001291412; NP_001291413; NP_001317302;
	NP_001317303; NP_640334; NP_001357226; NP_001357227; NP_001371055; NP_001371056; NP_001371057; NP_001371059; NP_001371060; NP_001371061; NP_001291412.1
	NP_001288746; NP_001288747; NP_631978
	Wikidata
View/Edit Human	View/Edit Mouse

FYVE, RhoGEF and PH domain-containing protein 4 is a protein encoded in humans by the FGD4 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000139132 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022788 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ikeda W, Nakanishi H, Takekuni K, Itoh S, Takai Y (Aug 2001). "Identification of splicing variants of Frabin with partly different functions and tissue distribution". Biochem Biophys Res Commun. 286 (5): 1066–72. doi:10.1006/bbrc.2001.5481. PMID 11527409.
^ "Entrez Gene: FGD4 FYVE, RhoGEF and PH domain containing 4".

External links

GeneReviews/NCBI/NIH/UW entry on Charcot-Marie-Tooth Neuropathy Type 4

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000139132 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022788 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11527409-5] Ikeda W, Nakanishi H, Takekuni K, Itoh S, Takai Y (Aug 2001). "Identification of splicing variants of Frabin with partly different functions and tissue distribution". Biochem Biophys Res Commun. 286 (5): 1066–72. doi:10.1006/bbrc.2001.5481. PMID 11527409.

[entrez-6] "Entrez Gene: FGD4 FYVE, RhoGEF and PH domain containing 4".

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FGD4

See also

References

Further reading

External links