Wilkerson was born to Traci and Gene Wilkerson and has a sister, Olivia. Wilkerson and his sister are both para swimmers with leber congenital amaurosis.[2][3]
On September 25, 2023, Wilkerson was named to team USA's roster to compete at the 2023 Parapan American Games.[5] He made his international debut at the event and won a silver medal in the 100 meter backstroke S12 and a bronze medal in the 100 meter breaststroke SB12 events.[6][7]
On June 30, 2024, Wilkerson was named to team USA's roster to compete at the 2024 Summer Paralympics.[8]