Esra Özkan obtained her license on November 15, 2007. She entered Marmara Üniversitesispor in the 2008–09 season. She played five full seasons, of which two were in the Turkish Women's First season. In the mid of the 2013–14 First League season, she transferred to Ataşehir Belediyespor.[2] She was capped 77 times and scored 27 goals with Marmara Üniversitesispor.[1]
Özkan serves as the captain of the girls' football team at her high school, which is a top-ranking team of the Turkish High School Girls' Football Championship.[3][4][5] She plays also futsal in her school team. She was part of the team representing Turkey at the 2014 ISF World Schools Futsal Championship held in Italy that became champion in the girls' category.[6][7]
In the second half of the 2014–15 season, she transferred to Istanbul-based Second League team Kireçburnu Spor. At the end of the season, her team enjoyed promotion to the Women's First League.[8]
Özkan stayed the following two seasons away from the football pitch. In December 2017, in the mid of the 2017–18 season, she transferred to the Women's Third League club Çerkezköy 1923 Gençlik Spor. After scoring two goals in nine matches, she retired.[1]