Mario was a registered pharmacist in the State of New York and worked as a community pharmacist during his early career.
After completing his graduate work, he began a career in the pharmaceutical industry, beginning as a researcher for Strasenburgh Laboratories in Rochester, New York. He subsequently held positions with SmithKline & French in Philadelphia, PA; E.R. Squibb & Sons in New Brunswick, NJ and Princeton, NJ; and Glaxo Inc. in Research Triangle Park, North Carolina.[1]
From 1989 to 1993, he was the chief executive of Glaxo Holdings, plc., a company headquartered in London, England. He served as deputy chairman of the board and CEO of Glaxo Holdings from 1992 to 1993.[1][4] He was the chairman and CEO of Alza Corporation, based in Palo Alto, California, from 1993 until the company was purchased by Johnson & Johnson, Inc., in 2001. After Alza, Mario became chairman and CEO of Reliant Pharmaceuticals, based in Liberty Corner, New Jersey. He was also the non-executive chairman of Pharmaceutical Product Development, Inc, based in Wilmington, North Carolina, from 1993 to 2009. In April 2010, he was appointed to the board of directors for Vivus Pharmaceuticals. He has served on numerous other public corporate boards, as well as several non-profits.[1][5]
Trustee of Duke University
Mario served as a trustee of Duke University from 1989 to 2007, and chaired the Duke University Health System board of trustees from its inception until 2007. On July 1, 2007, he became a trustee emeritus of Duke University. In 2009 he was awarded The University Medal, Duke's highest recognition of service to the school. His 18 years on the Duke University board made him the second longest serving trustee in the school's history.[a]Duke lowered it’s flag to half mast on October 22, 2024 to honor his legacy of service to the university and the health system. [1]
Death
Mario died of pancreatic cancer at his son’s home in Durham, North Carolina, on October 20, 2024, at the age of 86. He had been diagnosed with the cancer six months earlier.[6]
A memorial was held on December 7th, 2024, at the Edith Memorial Chapel on the campus of The Lawrenceville School in Lawrenceville, NJ, for both Ernest and his wife of 59 years, Mildred Mario. Mildred died on April 17th, 2020, but had no prior memorial due to the COVID pandemic.
In 2007, Mario was recognized for a lifetime of service to the profession of pharmacy when the American Pharmacists Association awarded him the Remington Medal, the highest award in professional pharmacy. He is the 79th Remington Medalist.[9]