The house was built in a bungalow/craftsman style 1917 and designed by architect R.A. Gray, who is best known for having designed St. Mary's Church, and was built by contractor Tom Weatherford.[3]
It was listed as part of a study of historic resources in the Roosevelt neighborhood which compared the popularity of the Spanish Colonial Revival style with that of the Craftsman Bungalow.[4][5]
William Ellis moved to Phoenix from Ohio in 1907 and worked as Chief of the Medical Staff of what was then Arizona Deaconess Hospital. He had the house built about a mile from his offices for Reba, his second wife, and his daughter Helen.[6] Ellis's daughter and her husband, J. Gordon Shackelford, for whom the house is also named, called the house home until 1964 and Shackelford added a dentist's office to the property in 1947. Subsequently, the property became a boys' home before becoming home to the Arizona Historical Society and its offices and the Phoenix Trolley Museum in what was the dental office.[6] The home underwent a nine-month renovation in 2012-2013, and as of 2024, the building is owned by the city of Phoenix and is home to Arizona Humanities, the state National Endowment for the Humanities affiliate.[2][7]
In 2016, Amy Ellis Shackelford, great-great granddaughter of William Ellis, became the fourth generation in her family to celebrate a wedding at the house when she married Aaron Aguirre on March 12.[8]